Document Detail


Deer velvet supplementation decreases the grade and metastasis of azoxymethane-induced colon cancer in the male rat.
MedLine Citation:
PMID:  20176070     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Since deer velvet (DV) extract promotes angiogenesis, its ability to modulate the growth and invasiveness of colon tumours was investigated. Male Wistar rats were each given a subcutaneous injection of azoxymethane (AOM) at 15 mg/kg once a week for 3 weeks. One week following the last dose of AOM the rats received either 1g/kg of DV delivered in a cube of raspberry gelatin or plain raspberry gelatin daily for 26 weeks. At necropsy, tumours were measured and the distance from the anus was recorded. Tissue samples were categorised according to the Astler-Coller system. The results showed that there were no significant differences in most parameters examined (i.e. body weight gain, multiplicity, tumour volume and incidence). The only statistically significant differences seen were associated with metastasis and tumour grade. Specifically, more of the tumours in the DV-treated rats were of a lower grade compared to the controls, both when all tumour sites were considered (0.91 vs. 0.66, p<0.0001), as well as those located only in the colon (0.95 vs. 0.84, p<0.03). Therefore, this study can confidently conclude that DV does not increase the incidence, multiplicity, metastasis or tumour volume of AOM-induced colon cancer in the rat.
Authors:
A Fraser; S R Haines; E C Stuart; M J Scandlyn; A Alexander; T J Somers-Edgar; R J Rosengren
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-02-20
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  48     ISSN:  1873-6351     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-14     Completed Date:  2010-07-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1288-92     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 Elsevier Ltd. All rights reserved.
Affiliation:
Gribbles Veterinary Pathology, Palmerston North, New Zealand.
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / classification,  drug therapy*,  secondary
Animals
Antineoplastic Agents / pharmacology*
Azoxymethane / toxicity
Colonic Neoplasms / classification,  drug therapy*,  pathology
Disease Models, Animal
Male
Neoplasm Metastasis / drug therapy,  prevention & control
Rats
Rats, Wistar
Skin / chemistry*
Tissue Extracts / pharmacology*
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Tissue Extracts; 25843-45-2/Azoxymethane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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