Document Detail

Deep venous thrombosis and previous myocardial infarction in mild factor XII deficiency: a risk factor for both venous and arterial thrombosis.
MedLine Citation:
PMID:  18392695     Owner:  NLM     Status:  MEDLINE    
Factor XII deficiency is associated with increased risk for both arterial and venous thrombosis. We describe a case of DVT involving superficial femoral and popliteal vein occurred following total hip replacement and despite prophylaxis with low molecular weight heparin in a subject with previous acute myocardial infarction (AMI). Tests of haemostasis documented a slightly prolonged activated partial thromboplastin time (APTT) (45'') due to mild factor XII deficiency (clotting activity 32%). A therapeutic dose of enoxaparin was started, together with warfarin therapy. The patient was advised to continue oral anticoagulation indefinitely. Although cases of both venous and arterial thrombosis in carriers of severe factor XII deficiency have been already reported, to our knowledge this is the first case in the literature occurred in a carrier of partial factor XII deficiency. In conclusion, factor XII deficiency should be suspected if a patient presents with recurrent arterial and/or venous thrombosis and prolonged APTT. If this defect is diagnosed, in the presence of a history of thrombotic events, lifelong anticoagulation could be considered.
Gianfranco Lessiani; Angela Falco; Elvira Nicolucci; Giancarlo Rolandi; Giovanni Davì
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2008-04-06
Journal Detail:
Title:  Journal of thrombosis and thrombolysis     Volume:  27     ISSN:  1573-742X     ISO Abbreviation:  J. Thromb. Thrombolysis     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-04-06     Completed Date:  2009-07-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9502018     Medline TA:  J Thromb Thrombolysis     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  348-51     Citation Subset:  IM    
Villa Serena Hospital, Pescara, Italy.
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MeSH Terms
Arterial Occlusive Diseases / etiology
Factor XII Deficiency / complications*,  diagnosis*
Myocardial Infarction / etiology*
Partial Thromboplastin Time
Risk Factors
Thrombosis / etiology
Venous Thrombosis / etiology*
Comment In:
J Thromb Thrombolysis. 2009 May;27(4):454-5   [PMID:  19283451 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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