| Deep vein thrombosis and systemic inflammatory response: a pilot trial. | |
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MedLine Citation:
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PMID: 12674687 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Symptoms of deep vein thrombosis as swelling, erythema, pain and calor have been suspected of being caused by an inflammatory reaction of the affected leg. We therefore performed a prospective pilot trial to study a possible systemic inflammatory response induced by deep vein thrombosis. PATIENTS AND METHODS: We determined white blood cell count and plasma C-reactive protein in 100 consecutive patients with suspected deep vein thrombosis. The final diagnosis was based on the results of duplex sonography or ascending venography. RESULTS: Deep vein thrombosis was diagnosed in 37 patients (37%). White blood cell count (P = 0.012) and plasma C-reactive protein values (P < 0.001) were significantly increased in patients suffering from deep vein thrombosis. There was no correlation of white blood cell count or C-reactive protein with the thrombotic burden or the duration of symptoms. CONCLUSION: In patients with deep vein thrombosis, thrombus formation and consequent vein wall damage induce a systemic inflammatory reaction which is reflected by significantly increased levels of white blood cells and plasma C-reactive protein. |
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Authors:
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Markus Reiter; Robert A Bucek; Nihat Koca; Albert Dirisamer; Erich Minar |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Wiener klinische Wochenschrift Volume: 115 ISSN: 0043-5325 ISO Abbreviation: Wien. Klin. Wochenschr. Publication Date: 2003 Feb |
Date Detail:
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Created Date: 2003-04-04 Completed Date: 2003-06-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 21620870R Medline TA: Wien Klin Wochenschr Country: Austria |
Other Details:
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Languages: eng Pagination: 111-4 Citation Subset: IM |
Affiliation:
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Department of Angiology, University Clinic, General Hospital, Vienna, Austria. markus.reiter@akh-wien.ac.at |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute-Phase Reaction
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blood,
physiopathology Adult Aged C-Reactive Protein / analysis* Data Interpretation, Statistical Female Humans Inflammation / blood, physiopathology* Leukocyte Count* Male Middle Aged Multivariate Analysis Phlebography Pilot Projects Prospective Studies Thrombophlebitis / physiopathology*, radiography, ultrasonography Ultrasonography, Doppler, Duplex |
| Chemical | |
Reg. No./Substance:
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9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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