Document Detail

Deep vein thrombosis: scintigraphic diagnosis with In-111-labeled monoclonal antifibrin antibodies.
MedLine Citation:
PMID:  2678259     Owner:  NLM     Status:  MEDLINE    
Fifty-two patients suspected of having deep vein thrombosis under-went scintigraphy with an indium-111-labeled monoclonal antifibrin antibody. Venography disclosed deep vein thrombosis in 31 patients. With the whole limb considered an anatomic entity, antifibrin antibody scintigrams obtained 2 hours after injection had a specificity and sensitivity of 81% and 84%, respectively. A higher sensitivity (92%) was found for a subgroup of patients (n = 44) with symptoms for less than 10 days. Regional sensitivities for all patients and for the subgroup, respectively, were 92% and 100% in the calf, 82% and 94% in the popliteal region, 63% and 71% in the thigh, and only 18% and 13% in the pelvis. Additional imaging performed 6 hours and 21 hours after injection in 12 patients and quantitative analysis done from scintigrams with and without blood-pool (technetium-99m human serum albumin) correction did not improve sensitivity. In-111-antifibrin antibody scintigraphy is an accurate method for diagnosis of acute established deep vein thrombosis of the calf and popliteal region; its sensitivity in the thigh is lower, and it is not feasible for diagnosis in the pelvic area.
M Jung; K Kletter; R Dudczak; R Koppensteiner; E Minar; P Kahls; A Stümpflen; P Pokieser; H Ehringer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Radiology     Volume:  173     ISSN:  0033-8419     ISO Abbreviation:  Radiology     Publication Date:  1989 Nov 
Date Detail:
Created Date:  1989-11-14     Completed Date:  1989-11-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0401260     Medline TA:  Radiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  469-75     Citation Subset:  AIM; IM    
Division of Angiology, University of Vienna Medical School, Austria.
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MeSH Terms
Antibodies, Monoclonal / diagnostic use*
Fibrin / immunology*
Indium Radioisotopes / diagnostic use*
Leg / blood supply
Middle Aged
Sensitivity and Specificity
Thrombophlebitis / radiography,  radionuclide imaging*
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Indium Radioisotopes; 9001-31-4/Fibrin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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