Document Detail

Deep vein thrombosis: beyond the operating table.
MedLine Citation:
PMID:  10875426     Owner:  NLM     Status:  MEDLINE    
Deep vein thrombosis (DVT) is of clinical importance and carries the short-term risk of pulmonary embolism. Patients undergoing orthopedic surgery are at particular risk of DVT. Pharmacological prophylaxis to prevent thromboembolic events has become standard practice in this patient group. However, DVT may also lead to long-term venous insufficiency, causing disabling symptoms of swelling, chronic pain, and skin ulceration, imposing substantial health-care costs. Prevention of these long-term sequelae of DVT, termed post-thrombotic syndrome (PTS), may be of equal or even greater clinical, economic, and medicolegal significance than avoidance of the short-term effects. Surveys suggest that PTS is present in 30%-70% of patients, 5 years after an initial symptomatic or asymptomatic, proximal or distal DVT. Post-thrombotic syndrome is not reliably prevented by treatment of the initial DVT with anticoagulant therapy or thrombolysis. Therefore, prevention of DVT is the only effective approach to PTS prevention. Pharmacological thromboprophylaxis prevents venographically proven DVT in patients following orthopedic surgery, and is now recommended by North American and European consensus statements. Uncertainties remain, however, regarding the optimal duration of postsurgical prophylaxis.
S Haas
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Orthopedics     Volume:  23     ISSN:  0147-7447     ISO Abbreviation:  Orthopedics     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-11-28     Completed Date:  2000-11-28     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7806107     Medline TA:  Orthopedics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  s629-32     Citation Subset:  IM    
Institute for Experimental Oncology and Therapeutic Research, Technical University of Munich, Germany.
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MeSH Terms
Anticoagulants / therapeutic use
Postoperative Complications / prevention & control
Pulmonary Embolism / etiology
Risk Assessment
Risk Factors
Socioeconomic Factors
Venous Thrombosis / complications,  prevention & control*
Reg. No./Substance:

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