| Deep sedation with propofol in patients with Rett syndrome. | |
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MedLine Citation:
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PMID: 17005101 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Herein we present the largest retrospective case-control series of deep sedation in patients with Rett syndrome, including discussion of the unique aspects of Rett syndrome that make these patients at high risk for sedation. Twenty-one patients with Rett syndrome and 21 control patients who received propofol for deep sedation to facilitate lumbar puncture were compared. Patients with Rett syndrome required significantly less propofol than control patients when standardized for weight and the duration of the procedure (P = .004). Seven of the 21 patients with Rett syndrome compared with none of the control patients experienced a serious adverse event, most of which were due to prolonged apnea (P = .004). All adverse events were transient, and all patients returned to their baseline after the procedure was completed. Sedation of patients with Rett syndrome is associated with a relatively high rate of complications and should not be done without appropriate personnel available who recognize the risks of sedating this unique population. |
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Authors:
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Nancy M Tofil; Mark A Buckmaster; Margaret K Winkler; Beth H Callans; Monica P Islam; Alan K Percy |
Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of child neurology Volume: 21 ISSN: 0883-0738 ISO Abbreviation: J. Child Neurol. Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2006-09-28 Completed Date: 2007-02-20 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 8606714 Medline TA: J Child Neurol Country: Canada |
Other Details:
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Languages: eng Pagination: 857-60 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Division of Critical Care, University of Alabama, Birmingham, AL 35233, USA. ntofil@peds.uab.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Case-Control Studies Child Child, Preschool Female Humans Hypnotics and Sedatives / administration & dosage*, adverse effects* Male Propofol / administration & dosage*, adverse effects* Retrospective Studies Rett Syndrome / cerebrospinal fluid, complications* Spinal Puncture / drug effects, methods |
| Grant Support | |
ID/Acronym/Agency:
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HD38985/HD/NICHD NIH HHS; HD40301/HD/NICHD NIH HHS; M01 RR00032/RR/NCRR NIH HHS; RR019478/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Hypnotics and Sedatives; 2078-54-8/Propofol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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