Document Detail


Deep sea immunity: unveiling immune constituents from the hydrothermal vent mussel Bathymodiolus azoricus.
MedLine Citation:
PMID:  17291578     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Marine molluscs are subjected to constant microbial threats in their natural habitats. As a result, they represent suitable models for the study of the molecular mechanisms that govern defense reactions in marine organisms. To understand humoral and cellular defense reactions in animals defying extreme physical and chemical conditions we set out to investigate the deep sea hydrothermal vent mussel Bathymodiolus azoricus found in abundance at the Mid-Atlantic Ridge. In the present study, hemocytes were stimulated with compounds of microbial origin and cellular morphological alterations as well as the production of superoxide assessed. Consequently, zymosan, glucan and peptidoglycan were considered as potent inducers of cellular reactions for inducing drastic cell morphology changes and high levels of superoxide production. Furthermore, we have presented for the first time in a deep sea hydrothermal vent animal, molecular evidence of the Rel-homology domain, a conserved motif present in all members of the Rel/nuclear-factor NF-kappaB family. Additionally we have demonstrated the occurrence of the antibacterial gene mytilin in Bathymodiolus azoricus gill tissues. Our results support the premise of an evolutionary conserved innate immune system in Bathymodiolus. Such system is seemingly homologous to that of Insects and other Bivalves and may involve the participation of NF-kappaB transcription factors and antibacterial genes.
Authors:
Raul Bettencourt; Philippe Roch; Sergio Stefanni; Domitília Rosa; Ana Colaço; Ricardo Serrão Santos
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-01-05
Journal Detail:
Title:  Marine environmental research     Volume:  64     ISSN:  0141-1136     ISO Abbreviation:  Mar. Environ. Res.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-03     Completed Date:  2007-09-24     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9882895     Medline TA:  Mar Environ Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  108-27     Citation Subset:  IM    
Affiliation:
IMAR/Department of Oceanography and Fisheries, Genetics and Molecular Laboratory, University of the Azores, Rua Comendador Fernando da Costa, 9901-862 Horta, Portugal. raul@notes.horta.uac.pt
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Motifs
Animals
Antimicrobial Cationic Peptides / chemistry,  genetics
Immunity, Innate / physiology*
Immunologic Factors / chemistry,  genetics,  metabolism
Microbial Sensitivity Tests
Molecular Sequence Data
Mytilidae / genetics,  immunology*,  metabolism
NF-kappa B / chemistry,  metabolism
Oceans and Seas
Phylogeny
RNA, Messenger / metabolism
Sequence Alignment
Sequence Homology, Amino Acid
Chemical
Reg. No./Substance:
0/Antimicrobial Cationic Peptides; 0/Immunologic Factors; 0/NF-kappa B; 0/RNA, Messenger; 0/mytilin

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