Document Detail

Deep lamellar keratoplasty with lyophilised tissue in the management of keratoconus.
MedLine Citation:
PMID:  11423449     Owner:  NLM     Status:  MEDLINE    
AIMS: Data are presented on the use of deep lamellar keratoplasty (DLK) using lyophilised donor corneal tissue, in the management of patients with keratoconus (KC). METHOD: The results of DLK on 44 eyes (42 patients) are reported. The mean patient age was 29.8 years (range 10-56). Mean follow up was 25 months (range 6-100). In seven patients with mental handicap or severe mental illness, the collection of acuity and refractive data was limited. RESULTS: Perforation of Descemet's membrane (DM) occurred in nine cases (20%). A double anterior chamber formed in five cases, which resolved spontaneously in three patients. Persistent epithelial defects occurred in two cases, one of which necessitated replacement of the graft. The median postoperative uncorrected visual acuity was 6/36. The median corrected postoperative acuity was 6/9. Those with more than 1 year of follow up (n=25) had a significantly better acuity (p=0.015). This group achieved 6/12 or better in 80% (n=20) and 6/6 or better in 40% (n=10). The mean postoperative spherical error was +0.28 (SD 3.49) dioptres (D). The mean refractive cylinder was 3.85 (1.87) D. CONCLUSION: This detailed retrospective study of DLK for the treatment of patients with KC, with an average follow up of 2 years, highlights the advantages and disadvantages of this technique.
A G Coombes; J F Kirwan; C K Rostron
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of ophthalmology     Volume:  85     ISSN:  0007-1161     ISO Abbreviation:  Br J Ophthalmol     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-06-25     Completed Date:  2001-07-26     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0421041     Medline TA:  Br J Ophthalmol     Country:  England    
Other Details:
Languages:  eng     Pagination:  788-91     Citation Subset:  IM    
Department of Ophthalmology, St George's Hospital, London, UK.
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MeSH Terms
Anterior Chamber / pathology
Descemet Membrane / injuries
Follow-Up Studies
Keratoconus / physiopathology,  surgery*
Keratoplasty, Penetrating / methods*
Middle Aged
Postoperative Complications
Retrospective Studies
Statistics, Nonparametric
Visual Acuity

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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