Document Detail

Deep inhalation prevents the respiratory elastance response to methacholine in rats.
MedLine Citation:
PMID:  16627875     Owner:  NLM     Status:  MEDLINE    
The bronchodilator effect of deep inhalation (DI) may be assessed from the time course of respiratory system resistance (Rrs) and reactance (Xrs) measured by the forced oscillation technique at a single frequency. The aim of the study was to assess the effect of DI in the closed chest rat. Under anesthesia and mechanical ventilation, seven Brown Norway rats were given regular DI (BN-di) and six underwent continuous tidal ventilation (BN) throughout an otherwise similar methacholine (Mch) challenge protocol. Rrs and Xrs were monitored at 20 Hz and apparent respiratory system elastance (Ers) was computed from Xrs. After Mch nebulization, there was a significant increase in Rrs and Ers compared with saline. Ers, but not Rrs, decreased after the DI and BN-di were found to have lower Ers than BN. Thus, DI significantly alters Ers and its response to Mch. Computer simulations suggested reversal of increased viscoelasticity and/or inhomogeneous behavior by the DI in that model.
Cyril Schweitzer; Bruno Demoulin; Gaelle Bello; Noelle Bertin; Anne Laure Leblanc; François Marchal
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric research     Volume:  59     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-04-21     Completed Date:  2006-06-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  646-9     Citation Subset:  IM    
Laboratoire de Physiologie, Faculté de Médecine, F-54505 Vandoeuvre les Nancy, France.
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MeSH Terms
Airway Resistance / drug effects,  physiology
Bronchial Hyperreactivity / diagnosis,  physiopathology
Bronchoconstrictor Agents / diagnostic use*
Inhalation / physiology*
Methacholine Chloride / diagnostic use*
Models, Animal
Rats, Inbred BN
Respiratory Function Tests / methods*
Reg. No./Substance:
0/Bronchoconstrictor Agents; 62-51-1/Methacholine Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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