Document Detail

Deep hypothermic circulatory arrest in patients with high cognitive needs: full preservation of cognitive abilities.
MedLine Citation:
PMID:  19101283     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Owing to controversy regarding the efficacy and safety of deep hypothermic circulatory arrest (DHCA) during thoracic aortic surgery, we conducted a psychometric study in which high-cognitive patients and their informants were interviewed to determine whether DHCA had any adverse effect on their daily activities or work performance. METHODS: A total of 29 patients (18 males, 11 females; age, 26 to 75 years; mean 52.6 years) whose jobs require high cognitive capability and who had undergone aortic surgery using DHCA (range, 17 to 54 minutes; mean arrest time, 27.4 minutes) at Yale-New Haven Hospital were retrospectively studied. These 29 patients represented the responders among 45 such patients to whom questionnaires were mailed. A control group of 21 high-cognitive patients (20 males, 1 female; ages, 36 to 77 years; mean, 54.7 years) who underwent aortic surgery without DHCA were surveyed as well. During surgery, DHCA was used as the sole means of cerebral protection. The head was packed in ice, and carbon dioxide flooding of the field was used in all cases. The ascending aorta was resected with an open distal anastomosis and a hemiarch or total arch replacement. A 21-part questionnaire (adapted from A.F. Jorm's Short Form IQCODE and supplemented by our own questions) was distributed postoperatively to subjects and to their informants (generally a spouse). A value of 3 on the questionnaire indicated "not much change" from preoperative status (1 indicated much worse and 5 indicated much improved). RESULTS: There were no statistically significant differences in any functional outcomes by study group (by patient: DHCA 3.01, control 3.09; by informant: DHCA 3.00, control 3.03; p > 0.05). Mean values of the outcomes for study groups and control subjects were essentially identical and quite close to 3 (the value assigned to "not much change") for overall score, for occupational score, and for memory-related score. CONCLUSIONS: These data indicate that high-cognitive patients experienced very little cognitive change as a result of undergoing DHCA. Our assessment strongly supports the adequacy of straight DHCA as a cerebral protectant strategy during short- to moderate-duration circulatory arrest. We found excellent preservation of functional state and no difference from patients undergoing aortic surgery without DHCA.
Andrew Percy; Shannon Widman; John A Rizzo; Maryann Tranquilli; John A Elefteriades
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  87     ISSN:  1552-6259     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-22     Completed Date:  2009-01-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  117-23     Citation Subset:  AIM; IM    
Section of Cardiothoracic Surgery, Yale University School of Medicine, New Haven, Connecticut 06437, USA.
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MeSH Terms
Aorta, Thoracic / surgery
Aortic Aneurysm, Thoracic / radiography,  surgery*
Blood Vessel Prosthesis Implantation / adverse effects,  methods
Case-Control Studies
Circulatory Arrest, Deep Hypothermia Induced / methods*
Cognition Disorders / prevention & control*
Follow-Up Studies
Middle Aged
Patient Satisfaction
Postoperative Care / methods
Preoperative Care / methods
Reference Values
Retrospective Studies
Risk Assessment
Treatment Outcome
Vascular Surgical Procedures / adverse effects,  methods

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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