Document Detail


Deep grey matter T2 hypo-intensity in patients with paediatric multiple sclerosis.
MedLine Citation:
PMID:  21228024     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objective: T2 hypo-intensity on magnetic resonance imaging scans is thought to reflect pathological iron deposition in the presence of disease. In this pilot study, we evaluated the utility of the quantification of T2 hypo-intensities in paediatric patients by estimating deep grey matter (DGM) T2 hypo-intensities in paediatric patients with multiple sclerosis (MS) or clinically isolated syndromes (CIS), and their changes over 1 year. Methods: A dual-echo sequence was obtained from 45 paediatric patients (10 with CIS, 35 with relapsing-remitting MS, 8 with an onset of the disease before the age of 10 and 37 during adolescence) and 14 age-matched healthy controls (HC). Eleven patients were reassessed both clinically and with MRI after 1 year. Normalized T2 intensity in the basal ganglia and thalamus was quantified. Results: At baseline, DGM T2 intensity was similar between paediatric patients and HC in all the structures analysed, except for the head of the left caudate nucleus (p = 0.001). DGM T2 intensity of the head of the left caudate nucleus was similar between paediatric CIS and RRMS patients, but it was reduced in adolescent-onset paediatric patients versus HC (p = 0.002). In all patients, DGM T2 intensity of the head of the left caudate nucleus was correlated with T2 lesion volume (r = -0.39, p = 0.007). DGM T2 intensity in all the structures analysed with longitudinal assessment remained stable over the follow-up in the cohort of patients. Conclusions: The quantification of DGM T2 intensity in paediatric patients may provide surrogate markers of neurodegeneration. In paediatric MS, DGM is likely to be affected by iron-related changes, which are likely to be, at least partially, secondary to WM damage.
Authors:
Antonia Ceccarelli; Maria A Rocca; Elisabetta Perego; Lucia Moiola; Angelo Ghezzi; Vittorio Martinelli; Giancarlo Comi; Massimo Filippi
Related Documents :
18613384 - Acid and bile reflux in erosive reflux disease, non-erosive reflux disease and barrett'...
15886624 - Oropharyngoesophageal scintigraphy in the diagnostic algorithm of laryngopharyngeal ref...
3175534 - Comparison of three methods of intraesophageal ph recordings in the diagnosis of gastro...
7658514 - Ultrasonographic signs of sliding gastric hiatal hernia and their prospective evaluation.
2006624 - Analysis of survival in patients with pulmonic valve atresia and ventricular septal def...
6859034 - Lymphocytotoxic antibody is a predictor of response to random donor platelet transfusion.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-12
Journal Detail:
Title:  Multiple sclerosis (Houndmills, Basingstoke, England)     Volume:  -     ISSN:  1477-0970     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9509185     Medline TA:  Mult Scler     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute/University Ospedale San Raffaele, Milan Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Promoting recruitment of minority ethnic groups into research: qualitative study exploring the views...
Next Document:  Effect of disease-modifying drugs on cortical lesions and atrophy in relapsing-remitting multiple sc...