Document Detail

Deep cervical lymph flow following the infusion of mannitol in rabbits.
MedLine Citation:
PMID:  9364197     Owner:  NLM     Status:  MEDLINE    
Jugular lymph flow of anesthetized rabbits in response to infusion of mannitol solutions differing in osmolarity were measured. Either an isotonic (310 mosmol), hypotonic (100 mosmol), or hypertonic (605 mosmol) mannitol solution was infused into either the internal carotid artery (ICA) or the right lateral ventricle (RLV). Lymph was collected continuously and measured over a 60 min preinfusion period, as well as during mannitol infusion and intermittent recovery periods. The mean peak flow rates of hypertonic infusion for the first 30 min via ICA and RLV were 2.2 +/- 0.4 (12% decrease) and 5.0 +/- 1.0 microliter/min (72% increase), over those of isotonic infusates which were 2.5 +/- 0.3 microliters/min (via ICA) and 2.9 +/- 0.5 microliters/min (via RLV), respectively. In contrast, lymph flow rates of hypotonic infusate for the first 30 min via ICA and RLV were 3.9 +/- 0.8 microliters/min and 2.3 +/- 0.4 microliters/min, respectively. A decrease both in intracranial pressure and in lymph flow following hypertonic mannitol infusion via ICA were observed. However, intracranial pressure and lymph formation were increased following hypertonic infusion via RLV. The results indicate that the changes in jugular lymph flow could be affected by the changing in osmolarity of mannitol infusate.
T T Tsay; J D Lin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Life sciences     Volume:  61     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1997  
Date Detail:
Created Date:  1997-12-09     Completed Date:  1997-12-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1929-34     Citation Subset:  IM    
Department of Physiology, China Medical College, Taichung, Taiwan, Republic of China.
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MeSH Terms
Diuretics, Osmotic / administration & dosage,  pharmacology*
Infusions, Intra-Arterial
Injections, Intraventricular
Lymph / drug effects*,  physiology*
Lymphatic System / drug effects,  physiology
Mannitol / administration & dosage,  pharmacology*
Osmolar Concentration
Reg. No./Substance:
0/Diuretics, Osmotic; 0/Solutions; 69-65-8/Mannitol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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