| Deep brain stimulation of the subthalamic nucleus in Parkinson's disease: similar improvements in saccadic and manual responses. | |
| | |
MedLine Citation:
|
PMID: 22266732 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
The purpose of this study was to determine whether the very large effects of saccadic latency distribution, generated by deep brain stimulation of the subthalamic nuclei are reflected in quantitatively corresponding changes for manual responses, rather than representing a reflection of the specific role of the subthalamus in controlling saccades. Saccadic and manual reaction times were measured under as nearly identical conditions as possible in six patients with implanted subthalamic electrodes and in six age-matched controls with the stimulation either on or off. Median latency was found to be reduced by stimulation in a similar way to saccadic latency; in neither case was there a significant change in the Linear Approach to Threshold with Ergotic Rate parameter σ. For both types of response, the effect is to move the responses proportionately in the direction of average of responses in the control group. We therefore conclude that the previously described effects of stimulation on latency are not a phenomenon peculiar to saccades, increasing confidence in using saccadic latency measurements as a surrogate for more general responses when determining the efficacy of deep brain stimulation. |
| | |
Authors:
|
Chrystalina A Antoniades; Roger H S Carpenter; Yasin Temel |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Neuroreport Volume: 23 ISSN: 1473-558X ISO Abbreviation: Neuroreport Publication Date: 2012 Feb |
Date Detail:
|
Created Date: 2012-01-23 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9100935 Medline TA: Neuroreport Country: England |
Other Details:
|
Languages: eng Pagination: 179-83 Citation Subset: IM |
Affiliation:
|
aNuffield Department of Clinical Neurosciences, Division of Clinical Neurology, John Radcliffe Hospital, University of Oxford bDepartment of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge, UK cDepartments of Neuroscience and Neurosurgery, Maastricht University Medical Centre, Maastricht, The Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: High-sodium intake aggravates myocardial injuries induced by aldosterone via oxidative stress in Spr...
Next Document: Metabolomic profiling of fatty acid and amino acid metabolism in youth with obesity and type 2 diabe...