Document Detail

Deep brain stimulation for medically refractory life-threatening status dystonicus in children.
MedLine Citation:
PMID:  22208329     Owner:  NLM     Status:  MEDLINE    
Generalized dystonic syndromes may escalate into persistent episodes of generalized dystonia known as status dystonicus that can be life-threatening due to dystonia-induced rhabdomyolysis and/or respiratory compromise. Treatment of these conditions usually entails parenteral infusion of antispasmodic agents and sedatives and occasionally necessitates a medically induced coma for symptom control. The authors report a series of 3 children who presented with medically intractable, life-threatening status dystonicus and were successfully treated with bilateral pallidal deep brain stimulation. Bilateral globus pallidus internus stimulation appears to be effective in the urgent treatment of medically refractory and life-threatening movement disorders.
Brian P Walcott; Brian V Nahed; Kristopher T Kahle; Ann-Christine Duhaime; Nutan Sharma; Emad N Eskandar
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of neurosurgery. Pediatrics     Volume:  9     ISSN:  1933-0715     ISO Abbreviation:  J Neurosurg Pediatr     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-02     Completed Date:  2012-02-13     Revised Date:  2013-08-15    
Medline Journal Info:
Nlm Unique ID:  101463759     Medline TA:  J Neurosurg Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  99-102     Citation Subset:  IM    
Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts, USA.
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MeSH Terms
Deep Brain Stimulation / methods*
Disease Progression
Dominance, Cerebral / physiology
Dystonic Disorders / etiology,  physiopathology,  therapy*
Follow-Up Studies
Globus Pallidus / physiopathology*
Neurologic Examination
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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