Document Detail


Deep brain stimulation in epilepsy with particular reference to the subthalamic nucleus.
MedLine Citation:
PMID:  12495878     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Alternative methods, for the treatment of medically refractory epileptic patients, who cannot be treated by resective surgery, such as chronic deep brain neurostimulation, are under development. Such methods have been used in the cerebellum, various thalamic nuclei, and in the caudate nucleus. In Grenoble, encouraged by the suppressive effects of pharmacological or electrical inhibition of the STN on different types of seizure in animal models of epilepsy, and by our experience with STN high frequency stimulation (HFS) in patients with movement disorders, we have evaluated the high frequency stimulation of the subthalamic nucleus (STN HFS). STN HFS was performed in five patients suffering from medically intractable seizures and considered unsuitable for resective surgery. A 67% to 80% reduction in seizure frequency was observed in three patients, with a partial symptomatic epilepsy of the central region. An additional patient suffering from severe myoclonic epilepsy (Dravet syndrome) also responded to STN HFS, with a weaker reduction of seizure frequency. The fifth patient who suffered from an autosomal dominant frontal lobe epilepsy with insulo-frontal seizures did not show any improvement. These results suggest that stimulation of STN could be a promising treatment for patients with drug-resistant epilepsy who would not benefit from conventional surgery.
Authors:
Stéphan Chabardès; Philippe Kahane; Lorella Minotti; Adnan Koudsie; Edouard Hirsch; Alim-Louis Benabid
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Epileptic disorders : international epilepsy journal with videotape     Volume:  4 Suppl 3     ISSN:  1294-9361     ISO Abbreviation:  Epileptic Disord     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-12-23     Completed Date:  2003-04-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  100891853     Medline TA:  Epileptic Disord     Country:  France    
Other Details:
Languages:  eng     Pagination:  S83-93     Citation Subset:  IM    
Affiliation:
Neurosurgery Department, CHU Michallon, BP 217 X, 38043 Grenoble Cedex, France. SChabardes@chu-grenoble.fr
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Basal Ganglia / physiology
Cerebellum / physiology
Child
Child, Preschool
Electric Stimulation Therapy*
Electrodes, Implanted
Electroencephalography
Epilepsy / surgery,  therapy*
Female
Humans
Male
Neural Pathways / physiology
Neurosurgical Procedures
Subthalamic Nucleus / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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