Document Detail


Deep brain stimulation in Tourette's syndrome: two targets?
MedLine Citation:
PMID:  16463374     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this report, we describe the effects of bilateral thalamic stimulation in one patient and of bilateral pallidal stimulation in another patient. Both patients suffered from intractable Tourette's syndrome (TS). Any conservative treatment had failed or had been stopped because of unbearable side effects in the 2 patients. In both cases, there was no comorbidity except for associated behavioral symptoms (compulsions). Electrodes were implanted at the level of the medial part of the thalamus (centromedian nucleus, the substantia periventricularis, and the nucleus ventro-oralis internus) in one patient and in the posteroventral part of the globus pallidus internus (GPi) in the other patient. In both cases, deep brain stimulation (DBS) resulted in a substantial reduction of tics and compulsions. These data show that bilateral DBS of the thalamus as well as of the GPi can have a good effect on tics and behavioral symptoms in patients suffering from intractable TS.
Authors:
Linda Ackermans; Yasin Temel; Danielle Cath; Chris van der Linden; Richard Bruggeman; Mariska Kleijer; Pieter Nederveen; Koen Schruers; Henry Colle; Marina A J Tijssen; Veerle Visser-Vandewalle;
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Publication Detail:
Type:  Case Reports; Comparative Study; Journal Article    
Journal Detail:
Title:  Movement disorders : official journal of the Movement Disorder Society     Volume:  21     ISSN:  0885-3185     ISO Abbreviation:  Mov. Disord.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-05-11     Completed Date:  2006-10-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8610688     Medline TA:  Mov Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  709-13     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2006 Movement Disorder Society.
Affiliation:
Department of Neurosurgery, University Hospital Maastricht, Maastricht, The Netherlands. ackermanslinda@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Deep Brain Stimulation / methods*
Follow-Up Studies
Globus Pallidus / radiation effects
Humans
Male
Middle Aged
Severity of Illness Index
Thalamus / radiation effects
Tourette Syndrome / pathology,  therapy*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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