| Deep brain stimulation: how does it work? | |
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MedLine Citation:
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PMID: 18540149 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Deep brain stimulation has significantly improved the motor symptoms in patients with Parkinson's disease (PD) and other movement disorders. The mechanisms responsible for these improvements continue to be explored. Inhibition at the site of stimulation has been the prevailing explanation for the symptom improvement observed with deep brain stimulation. Research using microelectrode recording during deep brain stimulation in the MPTP monkey model of PD has helped clarify how electrical stimulation of structures within the basal ganglia-thalamocortical circuit improves motor symptoms, and suggests that activation of output and the resultant change in pattern of neuronal activity that permeates throughout the basal ganglia motor circuit is the mechanism responsible for symptom improvement. |
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Authors:
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Jerrold L Vitek |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Cleveland Clinic journal of medicine Volume: 75 Suppl 2 ISSN: 0891-1150 ISO Abbreviation: Cleve Clin J Med Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-06-10 Completed Date: 2008-07-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8703441 Medline TA: Cleve Clin J Med Country: United States |
Other Details:
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Languages: eng Pagination: S59-65 Citation Subset: IM |
Affiliation:
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Neuromodulation Research Center, Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA. vitekj@ccf.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Basal Ganglia
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physiopathology Brain / physiopathology* Deep Brain Stimulation* Humans Movement Disorders / physiopathology, therapy* Parkinson Disease / physiopathology, therapy* Subthalamic Nucleus / physiopathology |
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