Document Detail

Deep brain stimulation for dystonia: patient selection and outcomes.
MedLine Citation:
PMID:  20590816     Owner:  NLM     Status:  MEDLINE    
In a literature survey, 341 patients with primary and 109 with secondary dystonias treated with deep brain stimulation (DBS) of the internal segment of the globus pallidus (GPi) were identified. In general, the outcomes for primary dystonias were more favourable compared to the secondary forms. For some secondary dystonias--like tardive dystonia, myoclonus-dystonia (M-D), NBIA (PANK2), the outcome was very good. Only for the primary generalized dystonias, the efficacy of GPi-DBS has been confirmed in randomised controlled trials. Predictors of outcome are the experience and dedication of the stereotactic team, the selection of patients--the diagnosis and pre-operative screening--and the quality of the post-operative care. Predictors of negative outcome are long duration of the disease--with contractures or scoliosis--and concomitant symptoms like spasticity and cerebellar dysfunction. More studies are required to establish the role of GPi-DBS in the treatment of secondary dystonias.
J D Speelman; M F Contarino; P R Schuurman; M A J Tijssen; R M A de Bie
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of neurology : the official journal of the European Federation of Neurological Societies     Volume:  17 Suppl 1     ISSN:  1468-1331     ISO Abbreviation:  Eur. J. Neurol.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-01     Completed Date:  2010-11-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9506311     Medline TA:  Eur J Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  102-6     Citation Subset:  IM    
Departments of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
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MeSH Terms
Deep Brain Stimulation / economics*,  methods*
Dystonia / classification,  economics*,  therapy*
Globus Pallidus / physiology
Patient Selection*
Retrospective Studies
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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