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Deep Brain Stimulation for Anorexia Nervosa.
MedLine Citation:
PMID:  22743198     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: Anorexia nervosa (AN) is a complex and severe, sometimes life-threatening psychiatric disorder with high relapse rates under standard treatment. After decades of brain lesioning procedure offered as the last resort, deep brain stimulation (DBS) came under investigation in the last few years as a treatment option for severe and refractory AN. METHODS AND RESULTS: In this jointly written article, Sun et al. (the Shanghai group) report an average of 65% increase in body weight after undergoing DBS procedure in 4 severe and refractory AN patients (average follow-up: 38 months). All patients weighed above 85% of expected body weight, thus no longer met the diagnostic criteria of AN at last follow-up. Nuttin et al. (the Leuven group) describe other clinical studies that provide evidence for the use of DBS for AN, and further discuss patient selection criteria, target selection, and adverse event of this evolving therapy. CONCLUSION: Preliminary results from the Shanghai group and other clinical centers showed that DBS for AN may be a valuable option for weight restoration in otherwise-refractory and life-threatening cases. The nature of this procedure, however, remains investigational and should not be viewed as a standard clinical treatment option. Further scientific investigation is essential to warrant the long-term efficacy and safety of DBS for AN.
Authors:
Hemmings Wu; Pieter Jan Van Dyck-Lippens; Remco Santegoeds; Kris van Kuyck; Loes Gabriëls; Guozhen Lin; Guihua Pan; Yongchao Li; Dianyou Li; Shikun Zhan; Bomin Sun; Bart Nuttin
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-25
Journal Detail:
Title:  World neurosurgery     Volume:  -     ISSN:  1878-8750     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101528275     Medline TA:  World Neurosurg     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Inc.
Affiliation:
Laboratory of Experimental Neurosurgery and Neuroanatomy, Katholieke Universiteit Leuven, Leuven, Belgium.
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