Document Detail

Dedifferentiation phenomena after denervation of mammalian adult vestibular receptors.
MedLine Citation:
PMID:  1751803     Owner:  NLM     Status:  MEDLINE    
The effect of transecting the vestibular nerve on the vestibular sensory epithelium was studied in adult guinea-pigs. When denervation was complete, after fifteen days, the vestibular hair cells began to show morphological features of immaturity. After two months, the majority of hair cells showed a supporting cell phenotype. By four months, both hair cells and supporting cells had become morphologically similar to the epithelial cells which line the vestibular cavities. When denervation was incomplete, hair cells and supporting cells retained their normal phenotype. This, plus the dedifferentiation after complete denervation, indicates that the phenotypes of the hair cells and supporting cells are innervation-dependent.
D Favre; A Sans
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuroreport     Volume:  2     ISSN:  0959-4965     ISO Abbreviation:  Neuroreport     Publication Date:  1991 Sep 
Date Detail:
Created Date:  1992-01-27     Completed Date:  1992-01-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  501-4     Citation Subset:  IM; S    
INSERM-U254, Laboratoire de Neurophysiologie sensorielle, Université de Montepellier, France.
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MeSH Terms
Age Factors
Cell Differentiation
Epithelium / pathology
Guinea Pigs
Hair Cells, Auditory / pathology*
Vestibular Nerve / injuries*

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