Document Detail


Dedifferentiated liposarcoma with rhabdomyoblastic differentiation.
MedLine Citation:
PMID:  16012847     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dedifferentiated areas of dedifferentiated liposarcoma (DDL) usually show malignant fibrous histiocytoma (MFH)- or fibrosarcoma-like features and lack any histologic signs of specific differentiation. However, some reports have demonstrated specific differentiation in these areas, with histologic features resembling those of rhabdomyosarcoma, leiomyosarcoma, and osteosarcoma. We report here a pathologic and genetic analysis of three cases of DDLs with rhabdomyosarcomatous areas. MFH- or fibrosarcoma-like areas of one primary DDL and two recurrent DDLs contained various amounts of rhabdomyoblasts, which were immunoreactive for desmin, myoglobin, muscle actin (HHF-35), and myogenin. An ultrastructural examination demonstrated rhabdomyoblasts with abundant cytoplasm containing thin and thick filaments and Z-bands. By real-time PCR, amplification of mdm2 and cdk4 was confirmed in both well-differentiated and dedifferentiated areas with rhabdomyoblasts of all cases. To our knowledge, only seven cases of DDLs with rhabdomyosarcomatous components have been reported, and furthermore, the genetic profiles of the rhabdomyosarcomatous components in DDLs have not been investigated. This study demonstrates that DDLs with rhabdomyosarcomatous areas have genetic alterations that are common to well-differentiated/dedifferentiated liposarcomas.
Authors:
Shio Shimada; Takashi Ishizawa; Keisuke Ishizawa; Kouichi Kamada; Takanori Hirose
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Publication Detail:
Type:  Journal Article     Date:  2005-07-13
Journal Detail:
Title:  Virchows Archiv : an international journal of pathology     Volume:  447     ISSN:  0945-6317     ISO Abbreviation:  Virchows Arch.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-11-30     Completed Date:  2006-04-20     Revised Date:  2012-06-25    
Medline Journal Info:
Nlm Unique ID:  9423843     Medline TA:  Virchows Arch     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  835-41     Citation Subset:  IM    
Affiliation:
Department of Pathology, Saitama Medical School, Morohongo 38, Moroyama, Iruma-gun, Saitama, 350-0495, Japan. shio@saitama-med.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Cell Transformation, Neoplastic
Cyclin-Dependent Kinase 4 / genetics,  metabolism*
DNA, Neoplasm / analysis
Female
Gene Dosage
Humans
Liposarcoma / genetics,  metabolism,  pathology*
Male
Middle Aged
Neoplasm Recurrence, Local
Proto-Oncogene Proteins c-mdm2 / genetics,  metabolism*
Retroperitoneal Neoplasms / genetics,  metabolism,  pathology*
Reverse Transcriptase Polymerase Chain Reaction
Rhabdomyosarcoma / genetics,  metabolism,  pathology*
Tumor Markers, Biological / metabolism
Chemical
Reg. No./Substance:
0/DNA, Neoplasm; 0/Tumor Markers, Biological; EC 2.7.11.22/CDK4 protein, human; EC 2.7.11.22/Cyclin-Dependent Kinase 4; EC 6.3.2.19/MDM2 protein, human; EC 6.3.2.19/Proto-Oncogene Proteins c-mdm2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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