| Decursin, an Active Compound Isolated from Angelica gigas, Inhibits Fat Accumulation, Reduces Adipocytokine Secretion and Improves Glucose Tolerance in Mice Fed a High-Fat Diet. | |
| | |
MedLine Citation:
|
PMID: 21972114 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Decursin (De), an active component of Angelica gigas, is known to exert anticancer and neuroprotective effects. However, its antiobesity and antidiabetic potential has not yet been investigated. This study evaluated the antiobesity effect of decursin, particularly focusing on its ability to inhibit adipocyte differentiation in 3 T3-L1 cells. Decursin treatment resulted in the inhibition of adipocyte differentiation and the expression of fatty acid synthase. The study further investigated these antiobesity effects using mice fed a normal diet (ND), a high-fat diet (HFD) and a HFD plus decursin 200 mg/kg diet (HFD + De) for 7 weeks. Mice administered HFD plus decursin showed a drastic decrease in weight gain, triglyceride content, total cholesterol content and fat size compared with those that received the HFD alone; this was observed despite similar quantities of total food intake. Furthermore, decursin improved glucose tolerance in mice fed a HFD. Finally, administration of decursin along with the HFD significantly reduced the secretion of HFD-induced adipocytokines such as leptin, resistin, IL-6 and MCP-1. These results suggest that decursin might be useful for the treatment of obesity and diabetes. Copyright © 2011 John Wiley & Sons, Ltd. |
| | |
Authors:
|
Jin-Taek Hwang; Sung Hee Kim; Haeng Jeon Hur; Hyun Jin Kim; Jae Ho Park; Mi Jeong Sung; Hye Jeong Yang; Shi Yong Ryu; Young Sup Kim; Mi Ran Cha; Myung Sunny Kim; Dae Young Kwon |
Related Documents
:
|
8808494 - The resistance of low density lipoprotein to oxidation promoted by copper and its use a... 20858904 - Fine mapping of the insulin-induced gene 2 identifies a variant associated with ldl cho... 2783074 - Low density lipoprotein subfractions and relationship to other risk factors for coronar... 7749854 - Patients with early-onset peripheral vascular disease have increased levels of autoanti... 15510694 - Improving data quality in community-based seafood consumption studies by use of two mea... 20159024 - Feeding rats a high fat/carbohydrate ratio diet reduces jejunal s/i activity ratio and ... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-10-4 |
Journal Detail:
|
Title: Phytotherapy research : PTR Volume: - ISSN: 1099-1573 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
|
Created Date: 2011-10-5 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8904486 Medline TA: Phytother Res Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 John Wiley & Sons, Ltd. |
Affiliation:
|
Department of Biogeron Food Technology, Korea Food Research Institute, Kyongki-do, Republic of Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A novel mutation in CRYBB1 associated with congenital cataract-microcornea syndrome: the p.Ser129Arg...
Next Document: Modulation of tumor necrosis factor related apoptosis-inducing ligand (TRAIL) receptors in a human o...