Document Detail

Decreasing arterial aging by controlling blood pressure levels and hypertension: a step forward.
MedLine Citation:
PMID:  23259559     Owner:  NLM     Status:  In-Data-Review    
Arterial aging, characterized by arterial stiffening that is clinically evaluable as aortic pulse wave velocity, is risky for CV events, disability, and loss of cognitive function. Today the only adopted strategy to decrease arterial aging/ arterial stiffness is represented by decreasing BP. Selective antihypertensive drug classes (calcium channel blockers, converting enzyme inhibitors, angiotensin type 1 receptor antagonists) showed a beneficial effect on the arterial wall and on both large and small arteries over and above the reduction in BP levels. Still, the lower the better paradigm seems only to expose older subjects to higher rate of side effects, that via hypotension result in even transient organ hypoperfusion. This vicious circle may be particularly detrimental for cerebral district and, thus, for cognitive impairment onset and progression until dementia.
Angelo Scuteri; Pedro Guimaraes Cunha
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current vascular pharmacology     Volume:  10     ISSN:  1875-6212     ISO Abbreviation:  Curr Vasc Pharmacol     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-12-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101157208     Medline TA:  Curr Vasc Pharmacol     Country:  United Arab Emirates    
Other Details:
Languages:  eng     Pagination:  702-4     Citation Subset:  IM    
UOC Geriatria, INRCA / IRCCS, Via Cassia 1167, 00189 Rome, Italy.
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