| Decreasing arterial aging by controlling blood pressure levels and hypertension: a step forward. | |
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MedLine Citation:
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PMID: 23259559 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Arterial aging, characterized by arterial stiffening that is clinically evaluable as aortic pulse wave velocity, is risky for CV events, disability, and loss of cognitive function. Today the only adopted strategy to decrease arterial aging/ arterial stiffness is represented by decreasing BP. Selective antihypertensive drug classes (calcium channel blockers, converting enzyme inhibitors, angiotensin type 1 receptor antagonists) showed a beneficial effect on the arterial wall and on both large and small arteries over and above the reduction in BP levels. Still, the lower the better paradigm seems only to expose older subjects to higher rate of side effects, that via hypotension result in even transient organ hypoperfusion. This vicious circle may be particularly detrimental for cerebral district and, thus, for cognitive impairment onset and progression until dementia. |
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Authors:
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Angelo Scuteri; Pedro Guimaraes Cunha |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Current vascular pharmacology Volume: 10 ISSN: 1875-6212 ISO Abbreviation: Curr Vasc Pharmacol Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-12-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101157208 Medline TA: Curr Vasc Pharmacol Country: United Arab Emirates |
Other Details:
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Languages: eng Pagination: 702-4 Citation Subset: IM |
Affiliation:
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UOC Geriatria, INRCA / IRCCS, Via Cassia 1167, 00189 Rome, Italy. angeloelefante@interfree.it. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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