Document Detail

Decreases in serum apolipoprotein B-100 and A-I concentrations in cows with milk fever and downer cows.
MedLine Citation:
PMID:  11858646     Owner:  NLM     Status:  MEDLINE    
Milk fever occurring during the peripartum period has been suggested to be caused by fatty liver developed during the non-lactating stage because diseased cows have increased serum concentrations of non-esterified fatty acids (NEFA) and show hepatic lipidosis. In cows with fatty liver and related diseases such as ketosis, serum concentrations of apolipoprotein (apo) B-100 and apoA-I are decreased. The purpose of the present study was to examine whether apoB-100 and apoA-I concentrations are similarly decreased in cows with milk fever. Apolipoprotein concentrations were also measured in cows with downer syndrome, which has been suggested to be related, at least in part, to milk fever. Compared with healthy cows during early lactation, apoB-100 and apoA-I concentrations were decreased in cows with milk fever and also in downer cows. In cows with milk fever, the decreases in apoB-100 and apoA-I concentrations were associated with increased NEFA and decreased cholesterol and phospholipid concentrations. However, in downer cows, serum lipid concentration changes were not as distinct as in cows with milk fever. These results, coupled with previous findings on the decreases in apoB-100 and apoA-I concentrations of cows with fatty liver-related diseases, suggest that fatty liver is involved in the development of milk fever and partly in that of downer cow syndrome.
Shin Oikawa; Norio Katoh
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Canadian journal of veterinary research = Revue canadienne de recherche vétérinaire     Volume:  66     ISSN:  0830-9000     ISO Abbreviation:  Can. J. Vet. Res.     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-02-22     Completed Date:  2002-06-05     Revised Date:  2013-04-18    
Medline Journal Info:
Nlm Unique ID:  8607793     Medline TA:  Can J Vet Res     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  31-4     Citation Subset:  IM    
Department of Veterinary Internal Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan.
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MeSH Terms
Apolipoprotein A-I / blood*
Apolipoprotein B-100
Apolipoproteins B / blood*
Cattle Diseases / blood*,  etiology
Fatty Liver / blood,  complications,  veterinary*
Ketosis / blood,  complications,  veterinary
Parturient Paresis / blood*,  etiology
Postpartum Period / blood
Puerperal Disorders / blood,  complications,  veterinary*
Reg. No./Substance:
0/Apolipoprotein A-I; 0/Apolipoprotein B-100; 0/Apolipoproteins B

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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