Document Detail

Decreases in fasting leptin and insulin concentrations after acute energy restriction and subsequent compensation in food intake.
MedLine Citation:
PMID:  15755824     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The decrease in leptin after energy restriction is a starvation signal to the brain. Several studies have found an association between this decrease and subjective appetite; however, no solid data are available on the acute decrease in fasting leptin concentration and subsequent caloric compensation. OBJECTIVE: The objective was to assess the effect of acute decreases in fasting leptin concentrations, induced by energy restriction, on subsequent energy intake compensation. We hypothesized that men with a large decrease in fasting leptin concentrations would have larger ad libitum energy intakes than would men with a small decrease in leptin. DESIGN: Thirty-four male unrestrained eaters [age: 23 +/- 3 y; body mass index (in kg/m(2)): 22.3 +/- 1.6] participated in a semicontrolled intervention study. Fasting serum leptin and insulin concentrations were measured before and 2 d after 62% energy restriction. Energy intake was measured on the 2 following days on which food was provided ad libitum. RESULTS: During energy restriction, fasting leptin and insulin concentrations decreased by 27.2% (95% CI: -34.4%, -19.9%) and 30.7% (95% CI: -41.0%, -20.4%), respectively. Subjects consumed 143 +/- 27% of their estimated energy requirements (18.3 +/- 2.9 MJ) on the first day and 124 +/- 20% (16.0 +/- 2.6 MJ) on the second day of ad libitum intake. No significant correlations were observed between decreases in fasting leptin or insulin concentrations and subsequent ad libitum energy intake; however, decreases in insulin were correlated with an increase in carbohydrate intake (r=-0.49, P < 0.01). CONCLUSION: Although fasting leptin concentrations decreased significantly during energy restriction and subjects showed compensatory behavior during subsequent ad libitum food intake, no association was observed between the decrease in fasting leptin concentrations and caloric compensation.
Monica Mars; Cees de Graaf; Lisette C P G M de Groot; Frans J Kok
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  81     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-03-09     Completed Date:  2005-04-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  570-7     Citation Subset:  AIM; IM    
Division of Human Nutrition, Wageningen University, Wageningen, Netherlands.
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MeSH Terms
Appetite / physiology
Confidence Intervals
Dietary Carbohydrates / administration & dosage*,  metabolism
Eating / physiology*
Energy Intake / physiology
Energy Metabolism / physiology
Fasting / blood*,  physiology
Insulin / blood*
Leptin / blood*
Nutritional Requirements
Odds Ratio
Starvation / blood,  physiopathology
Reg. No./Substance:
0/Dietary Carbohydrates; 0/Leptin; 11061-68-0/Insulin

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