| Decreased whole body lipolysis as a mechanism of the lipid-lowering effect of pioglitazone in type 2 diabetic patients. | |
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MedLine Citation:
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PMID: 19417125 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pioglitazone has been shown to reduce fasting triglyceride levels. The mechanisms of this effect have not been fully elucidated, but decreased lipolysis may contribute to blunt the hypertriglyceridemic response to a meal. To test this hypothesis, we studied 27 type 2 diabetes mellitus (T2DM) patients and 7 sex-, age-, and body mass index-matched nondiabetic controls. Patients were randomized to pioglitazone (45 mg/day) or placebo for 16 wk. Whole body lipolysis was measured [as the [(2)H(5)]glycerol rate of appearance (R(a))] in the fasting state and for 6 h following a mixed meal. Compared with controls, T2DM had higher postprandial profiles of plasma triglycerides, free fatty acid (FFA), and beta-hydroxybutyrate, and a decreased suppression of glycerol R(a) (P < 0.04) despite higher insulin levels [268 (156) vs. 190 (123) pmol/l, median (interquartile range)]. Following pioglitazone, triglycerides and FFA were reduced (P = 0.05 and P < 0.04, respectively), and glycerol R(a) was more suppressed [-40 (137) vs. +7 (202) mumol/min of placebo, P < 0.05] despite a greater fall in insulin [-85 (176) vs. -20 (58) pmol/l, P = 0.05]. We conclude that, in well-controlled T2DM patients, whole body lipolysis is insulin resistant, and pioglitazone improves the insulin sensitivity of lipolysis. |
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Authors:
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Amalia Gastaldelli; Arturo Casolaro; Demetrio Ciociaro; Silvia Frascerra; Monica Nannipieri; Emma Buzzigoli; Ele Ferrannini |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2009-05-05 |
Journal Detail:
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Title: American journal of physiology. Endocrinology and metabolism Volume: 297 ISSN: 1522-1555 ISO Abbreviation: Am. J. Physiol. Endocrinol. Metab. Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-06-26 Completed Date: 2009-08-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901226 Medline TA: Am J Physiol Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: E225-30 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antilipemic Agents
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pharmacology,
therapeutic use Diabetes Mellitus, Type 2 / drug therapy*, metabolism* Double-Blind Method Fasting / blood, metabolism Fatty Acids, Nonesterified / blood, metabolism Female Glycerol / blood, metabolism Humans Insulin / blood, metabolism Lipolysis / drug effects* Male Middle Aged Placebos Thiazolidinediones / pharmacology*, therapeutic use* Triglycerides / blood, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antilipemic Agents; 0/Fatty Acids, Nonesterified; 0/Placebos; 0/Thiazolidinediones; 0/Triglycerides; 11061-68-0/Insulin; 111025-46-8/pioglitazone; 56-81-5/Glycerol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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