Document Detail

Decreased whole body endogenous nitric oxide production in patients with primary pulmonary hypertension.
MedLine Citation:
PMID:  15665548     Owner:  NLM     Status:  MEDLINE    
Impaired pulmonary release of nitric oxide (NO) is one of the characteristic phenotypic changes of vascular cells in pulmonary hypertension. The aim of this study was to determine nitric oxide synthase (NOS)-dependent whole body NO production in patients with primary pulmonary hypertension. NOS-dependent whole body NO production was assessed by giving an intravenous infusion of L-[(15)N](2)-arginine (50 micromol/min for 30 min) and measuring isotopic urinary enrichment of (15)N-nitrite and (15)N-nitrate. Four female patients with no signs of infection were recruited and compared with 6 age-matched control subjects. Mean 12-hour excretion of (15)N-nitrite and (15)N-nitrate in the total urine over 36 h was smaller in patients than in control subjects (57.2 +/- 27.6 vs. 229.1 +/- 65.2 nmol/mmol creatinine, p < 0.01, Mann-Whitney U test, respectively). Neither mean 12-hour excretion of (14)N-nitrite and (14)N-nitrate (51.6 +/- 10.0 vs. 72.4 +/- 10.0 micromol/mmol creatinine, p = 0.3) nor glomerular filtration rates (84.5 +/- 15.8 vs. 129.7 +/- 16.0 ml/min, p = 0.1) were different between patients and control subjects. Our results suggest that either basal NOS-dependent whole body NO production is impaired or excess NO metabolism occurs in patients with primary pulmonary hypertension.
Eric A G Demoncheaux; Tim W Higenbottam; David G Kiely; Ju-Ming Wong; Simon Wharton; Richard Varcoe; Tom Siddons; Alan C Spivey; Keith Hall; Andy P Gize
Related Documents :
18321248 - Hypertensive encephalopathy presenting with isolated brain stem and cerebellar edema.
18642648 - Hyper flow and intracranial hypertension in diffuse axonal injury: an update to gennare...
6947868 - Hla antigens in spanish patients with essential hypertension.
24407598 - Effects of glutathione s-transferase t1 and m1 deletions on advanced carotid atheroscle...
24597828 - Relevance of novel inflammatory markers in stroke-induced immunosuppression.
1259798 - Effect of aspirin on liver tests in patients with ra or sle and in normal volunteers.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.     Date:  2005-01-21
Journal Detail:
Title:  Journal of vascular research     Volume:  42     ISSN:  1018-1172     ISO Abbreviation:  J. Vasc. Res.     Publication Date:    2005 Mar-Apr
Date Detail:
Created Date:  2005-04-15     Completed Date:  2005-05-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9206092     Medline TA:  J Vasc Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  133-6     Citation Subset:  IM    
Copyright Information:
Copyright 2005 S. Karger AG, Basel.
Division of Clinical Sciences (South), University of Sheffield, Royal Hallamshire Hospital, Sheffield, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Arginine / administration & dosage,  pharmacology
Case-Control Studies
Hypertension, Pulmonary / metabolism*
Injections, Intravenous
Middle Aged
Nitrates / urine
Nitric Oxide / biosynthesis*
Nitric Oxide Synthase / metabolism
Nitrites / urine
Nitrogen Isotopes
Grant Support
Reg. No./Substance:
0/Nitrates; 0/Nitrites; 0/Nitrogen Isotopes; 10102-43-9/Nitric Oxide; 74-79-3/Arginine; EC Oxide Synthase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Structural identification of oxidized acyl-phosphatidylcholines that induce platelet activation.
Next Document:  Comparison of the effect of pentoxifylline and captopril on proteinuria in patients with type 2 diab...