Document Detail


Decreased whole body endogenous nitric oxide production in patients with primary pulmonary hypertension.
MedLine Citation:
PMID:  15665548     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Impaired pulmonary release of nitric oxide (NO) is one of the characteristic phenotypic changes of vascular cells in pulmonary hypertension. The aim of this study was to determine nitric oxide synthase (NOS)-dependent whole body NO production in patients with primary pulmonary hypertension. NOS-dependent whole body NO production was assessed by giving an intravenous infusion of L-[(15)N](2)-arginine (50 micromol/min for 30 min) and measuring isotopic urinary enrichment of (15)N-nitrite and (15)N-nitrate. Four female patients with no signs of infection were recruited and compared with 6 age-matched control subjects. Mean 12-hour excretion of (15)N-nitrite and (15)N-nitrate in the total urine over 36 h was smaller in patients than in control subjects (57.2 +/- 27.6 vs. 229.1 +/- 65.2 nmol/mmol creatinine, p < 0.01, Mann-Whitney U test, respectively). Neither mean 12-hour excretion of (14)N-nitrite and (14)N-nitrate (51.6 +/- 10.0 vs. 72.4 +/- 10.0 micromol/mmol creatinine, p = 0.3) nor glomerular filtration rates (84.5 +/- 15.8 vs. 129.7 +/- 16.0 ml/min, p = 0.1) were different between patients and control subjects. Our results suggest that either basal NOS-dependent whole body NO production is impaired or excess NO metabolism occurs in patients with primary pulmonary hypertension.
Authors:
Eric A G Demoncheaux; Tim W Higenbottam; David G Kiely; Ju-Ming Wong; Simon Wharton; Richard Varcoe; Tom Siddons; Alan C Spivey; Keith Hall; Andy P Gize
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.     Date:  2005-01-21
Journal Detail:
Title:  Journal of vascular research     Volume:  42     ISSN:  1018-1172     ISO Abbreviation:  J. Vasc. Res.     Publication Date:    2005 Mar-Apr
Date Detail:
Created Date:  2005-04-15     Completed Date:  2005-05-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9206092     Medline TA:  J Vasc Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  133-6     Citation Subset:  IM    
Copyright Information:
Copyright 2005 S. Karger AG, Basel.
Affiliation:
Division of Clinical Sciences (South), University of Sheffield, Royal Hallamshire Hospital, Sheffield, UK.
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MeSH Terms
Descriptor/Qualifier:
Adult
Arginine / administration & dosage,  pharmacology
Case-Control Studies
Female
Humans
Hypertension, Pulmonary / metabolism*
Injections, Intravenous
Middle Aged
Nitrates / urine
Nitric Oxide / biosynthesis*
Nitric Oxide Synthase / metabolism
Nitrites / urine
Nitrogen Isotopes
Grant Support
ID/Acronym/Agency:
HL-60753/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Nitrates; 0/Nitrites; 0/Nitrogen Isotopes; 10102-43-9/Nitric Oxide; 74-79-3/Arginine; EC 1.14.13.39/Nitric Oxide Synthase

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