Document Detail

Decreased vitamin D levels in patients with familial mediterranean fever.
MedLine Citation:
PMID:  22187059     Owner:  NLM     Status:  Publisher    
Familial mediterranean fever (FMF) is an autosomal recessive disorder caused by mutations in the FMF gene (MEFV). The gene causing FMF, designated MEFV, encodes a protein called pyrin or marenostrin that is expressed mainly in myeloid bone marrow precursors, neutrophils, and monocytes. Since there are several etiological factors, FMF is the most common periodic fever syndrome. However, it is still unknown what triggers or ends these periodical attacks. As a pleiotropic hormone, vitamin D has immunomodulation effects. The aim of this study was to evaluate the vitamin D levels in FMF patients. The study group was comprised of 26 patients diagnosed with FMF (men/women: 12/14), and 34 healthy control (men/women: 17/17). Vitamin D levels in FMF patients and healthy controls were 11.05 ± 7.11, 17.15 ± 6.49, respectively. FMF patients had significantly decreased vitamin D levels compared with healthy controls (P < 0.001). In conclusion, it is thought that vitamin D deficiency in FMF patients may trigger the attacks. Further studies with larger patient populations need to hold to investigate the vitamin D deficiency in patients with FMF and that may assist to clarify the mechanism behind the colchicines resistant cases.
Bunyamin Kisacik; Suheyla Uzun Kaya; Yavuz Pehlivan; Turker Tasliyurt; Mehmet Sayarlioglu; Ahmet Mesut Onat
Related Documents :
22674589 - Dyselectrolytemia in acute kidney injury causing tetany and quadriparesis.
20345509 - Changes of gastric histology in patients with erosive oesophagitis receiving long-term ...
16553589 - An energy algorithm improves symptoms in some patients with gastroparesis and treated w...
2783669 - Occult gastrointestinal bleeding in high-risk intensive care unit patients receiving an...
6652009 - Gastric emptying following premedication with glycopyrrolate or atropine.
3989199 - Gastric emptying and small-bowel transit rate in the elderly.
2773619 - High frequency of cancer in cold thyroid nodules occurring at young age.
21286849 - Trace elements analysis of urine and hair in tuberculous pleurisy.
23704079 - Clinical manifestations of xq28 functional disomy involving mecp2 in one female and two...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-21
Journal Detail:
Title:  Rheumatology international     Volume:  -     ISSN:  1437-160X     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8206885     Medline TA:  Rheumatol Int     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Gaziantep University, 27100, Şahinbey, Gaziantep, Turkey,
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Assessment of the impact of proprioceptive exercises on balance and proprioception in patients with ...
Next Document:  Serum anti-cyclic citrullinated peptide antibodies may predict disease activity in rheumatoid arthri...