| Decreased ventilatory response to hypercapnia in dementia with Lewy bodies. | |
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MedLine Citation:
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PMID: 19475659 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A systematic autonomic dysfunction observed among patients with dementia with Lewy bodies (DLB) has recently attracted close attention. Here, we compare cardiovascular and pulmonary autonomic functions among patients with DLB, patients with Alzheimer's disease, and healthy control subjects. All 15 DLB patients demonstrated severely low ventilatory response to hypercapnia, whereas none of the other subjects demonstrated abnormal results. The majority of the DLB patients showed impaired heart rate variability, low uptake on (123)I-metaiodobenzylguanidine myocardial scintigraphy, and orthostatic hypotension. Ventilatory response to hypercapnia as a marker of respiratory autonomic function is a promising diagnostic tool for DLB. |
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Authors:
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Katsuyoshi Mizukami; Toshiaki Homma; Kazutaka Aonuma; Toru Kinoshita; Kenji Kosaka; Takashi Asada |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of neurology Volume: 65 ISSN: 1531-8249 ISO Abbreviation: Ann. Neurol. Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-06-03 Completed Date: 2009-06-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7707449 Medline TA: Ann Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 614-7 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, University of Tsukuba, Tsukuba City, Ibaraki, Japan. mizukami@md.tsukuba.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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3-Iodobenzylguanidine
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diagnostic use Aged Aged, 80 and over Alzheimer Disease / physiopathology Female Heart / physiopathology, radionuclide imaging* Heart Rate / physiology Humans Hypercapnia / etiology* Hypotension, Orthostatic / etiology Lewy Body Disease / complications* Male Myocardial Perfusion Imaging / methods Neuropsychological Tests Partial Pressure Tidal Volume / physiology Ventilation* |
| Chemical | |
Reg. No./Substance:
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77679-27-7/3-Iodobenzylguanidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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