Document Detail

Decreased ventilatory response to hypercapnia in dementia with Lewy bodies.
MedLine Citation:
PMID:  19475659     Owner:  NLM     Status:  MEDLINE    
A systematic autonomic dysfunction observed among patients with dementia with Lewy bodies (DLB) has recently attracted close attention. Here, we compare cardiovascular and pulmonary autonomic functions among patients with DLB, patients with Alzheimer's disease, and healthy control subjects. All 15 DLB patients demonstrated severely low ventilatory response to hypercapnia, whereas none of the other subjects demonstrated abnormal results. The majority of the DLB patients showed impaired heart rate variability, low uptake on (123)I-metaiodobenzylguanidine myocardial scintigraphy, and orthostatic hypotension. Ventilatory response to hypercapnia as a marker of respiratory autonomic function is a promising diagnostic tool for DLB.
Katsuyoshi Mizukami; Toshiaki Homma; Kazutaka Aonuma; Toru Kinoshita; Kenji Kosaka; Takashi Asada
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of neurology     Volume:  65     ISSN:  1531-8249     ISO Abbreviation:  Ann. Neurol.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-06-03     Completed Date:  2009-06-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7707449     Medline TA:  Ann Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  614-7     Citation Subset:  IM    
Department of Psychiatry, University of Tsukuba, Tsukuba City, Ibaraki, Japan.
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MeSH Terms
3-Iodobenzylguanidine / diagnostic use
Aged, 80 and over
Alzheimer Disease / physiopathology
Heart / physiopathology,  radionuclide imaging*
Heart Rate / physiology
Hypercapnia / etiology*
Hypotension, Orthostatic / etiology
Lewy Body Disease / complications*
Myocardial Perfusion Imaging / methods
Neuropsychological Tests
Partial Pressure
Tidal Volume / physiology
Reg. No./Substance:

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