Document Detail

Decreased ventilatory response to exercise by dopamine-induced inhibition of peripheral chemosensitivity.
MedLine Citation:
PMID:  19619673     Owner:  NLM     Status:  MEDLINE    
The contribution of the peripheral chemoreflex to the ventilatory response to exercise and aerobic exercise capacity remains incompletely understood. Low-dose dopamine has been reported to specifically inhibit the peripheral chemoreceptors. We therefore investigated the effects of intravenous dopamine (3 microg kg(-1)min(-1)) on cardiopulmonary exercise test (CPET) variables in 13 healthy young male subjects. The study was prospective, placebo-controlled, and randomized with more than 24h between placebo and dopamine administrations. During the CPET, dopamine decreased the .V(E)/.V(CO2) output slope (24.61+/-1.84 vs. 23.09+/-1.81, placebo vs. Dopamine respectively, p=0.025), without affecting maximum workload, .V(E) and O(2) uptake. In conclusion, our study reveals that inhibition of peripheral chemoreflex function with dopamine decreases the .V(E)/.V(CO2) slope during dynamic exercise, with no change in aerobic exercise capacity.
C Janssen; S Beloka; P Kayembe; G Deboeck; D Adamopoulos; R Naeije; P van de Borne
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2009-07-18
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  168     ISSN:  1878-1519     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-09-02     Completed Date:  2009-11-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  250-3     Citation Subset:  IM    
Department of Cardiology, Erasme University Hospital, 808 Lennik Road, Brussels, Belgium.
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MeSH Terms
Cardiotonic Agents / pharmacology*
Chemoreceptor Cells / drug effects*,  physiology
Dopamine / pharmacology*
Double-Blind Method
Exercise Tolerance / drug effects
Oxygen Consumption / drug effects*
Prospective Studies
Pulmonary Ventilation / drug effects*
Young Adult
Reg. No./Substance:
0/Cardiotonic Agents

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