| Decreased ventilatory response to exercise by dopamine-induced inhibition of peripheral chemosensitivity. | |
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MedLine Citation:
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PMID: 19619673 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The contribution of the peripheral chemoreflex to the ventilatory response to exercise and aerobic exercise capacity remains incompletely understood. Low-dose dopamine has been reported to specifically inhibit the peripheral chemoreceptors. We therefore investigated the effects of intravenous dopamine (3 microg kg(-1)min(-1)) on cardiopulmonary exercise test (CPET) variables in 13 healthy young male subjects. The study was prospective, placebo-controlled, and randomized with more than 24h between placebo and dopamine administrations. During the CPET, dopamine decreased the .V(E)/.V(CO2) output slope (24.61+/-1.84 vs. 23.09+/-1.81, placebo vs. Dopamine respectively, p=0.025), without affecting maximum workload, .V(E) and O(2) uptake. In conclusion, our study reveals that inhibition of peripheral chemoreflex function with dopamine decreases the .V(E)/.V(CO2) slope during dynamic exercise, with no change in aerobic exercise capacity. |
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Authors:
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C Janssen; S Beloka; P Kayembe; G Deboeck; D Adamopoulos; R Naeije; P van de Borne |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2009-07-18 |
Journal Detail:
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Title: Respiratory physiology & neurobiology Volume: 168 ISSN: 1878-1519 ISO Abbreviation: Respir Physiol Neurobiol Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-09-02 Completed Date: 2009-11-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101140022 Medline TA: Respir Physiol Neurobiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 250-3 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Erasme University Hospital, 808 Lennik Road, Brussels, Belgium. chrisrv.janssen@gmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cardiotonic Agents / pharmacology* Chemoreceptor Cells / drug effects*, physiology Dopamine / pharmacology* Double-Blind Method Exercise Tolerance / drug effects Humans Male Oxygen Consumption / drug effects* Prospective Studies Pulmonary Ventilation / drug effects* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Cardiotonic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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