Document Detail

Decreased vasomotor effect of endothelin on the coronary arteries during angioplasty in hypertensive patients.
MedLine Citation:
PMID:  8839809     Owner:  NLM     Status:  MEDLINE    
To investigate if the response of the contralateral artery during coronary angioplasty (PTCA) is different in hypertensive than in normotensive patients and whether this response is related to plasma levels of endothelin-1 (ET-1). We examined the change in ET-1 plasma levels and the reactivity of the left circumflex artery (LCx) during PTCA of the left anterior descending branch in 10 hypertensive and 23 normotensive patients. Peripheral vein blood samples were drawn for ET-1 estimation at baseline, after the end of the first balloon inflation, at the end of PTCA, and 4 h later. Angiograms of the LCx were obtained at baseline and during the 1st balloon inflation. The ET-1 level in hypertensives increased from 6.81 +/- 3.76 at baseline to 7.54 +/- 4.76 pmol/l (P = n.s.) at the end of PTCA, while in normotensives it increased from 8.21 +/- 3.73 to 11.56 +/- 5.04 pmol/l (F = 7.48, P = 0.0002) respectively. The LCx distal segment diameter increased from 1.29 to 1.50 mm during balloon inflation in hypertensive, and from 1.44 to 1.53 mm (F = 5.03, P = 0.03) in normotensives. The diameter increase was related to the baseline ET-1 level (r = -0.67, P = 0.005) in the normotensives, but not in the hypertensives. Thus ET-1 has a weaker vasomotion effect on the coronary vasculature in hypertensives than in normotensives during PTCA.
Z S Kyriakides; M Markianos; I A Paraskevaidis; D Tousoulis; N K Fragakis; D T Kremastinos
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of cardiology     Volume:  55     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1996-12-17     Completed Date:  1996-12-17     Revised Date:  2006-07-12    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  41-8     Citation Subset:  IM    
Onassis Cardiac Surgery Centre, Athens, Greece.
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MeSH Terms
Angioplasty, Transluminal, Percutaneous Coronary*
Blood Pressure
Coronary Vessels / physiopathology*
Endothelin-1 / blood*
Hypertension / blood,  complications,  physiopathology*
Middle Aged
Muscle, Smooth, Vascular / physiopathology*
Myocardial Ischemia / blood,  complications,  therapy*
Reg. No./Substance:

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