| Decreased vasoconstrictor responses in remote cerebral arteries after focal brain ischemia and reperfusion in the rat, in vitro. | |
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MedLine Citation:
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PMID: 20621085 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of brain ischemia and reperfusion on smooth muscle function in remote cerebral and peripheral arteries are hardly known. Maximum vasoconstrictions (E(max)) caused by 120mmol/l KCl and 5-HT in endothelium-denuded ring preparations were measured in ischemic and control cerebral arteries of rats after a 1-h right middle cerebral artery occlusion followed by 0-min (I/NR) or 2-3-min (I/SR) reperfusion, and in peripheral arteries after I/SR. Surprisingly, vasoconstrictions to 5-HT and 120mmol/lK(+) were attenuated in remote brain vessels after I/SR, i.e. in the contralateral middle cerebral artery and the basilar artery, while I/NR depressed E(max) of 5-HT and high KCl only in the ischemic middle cerebral artery. Pretreatment with N-(2-mercaptopropionyl) glycine (MPG, 100mg/kg i.p.), a free radical scavenger, fully prevented the impairment of vasomotor function in the middle cerebral artery on both sides after I/SR. Moreover, vasomotor functions were normal in the coronary, renal and pulmonary arteries after I/SR. In conclusion, focal cerebral ischemia and reperfusion impaired vasoconstrictor responses in remote brain arteries of rats by a mechanism involving free radicals. The lack of similar effects in peripheral vessels indicates poor defence of brain arteries against remote injury caused by reactive oxygen species-dependent mechanisms. |
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Authors:
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Anikó Kovács; Krisztina Móricz; Mihály Albert; Angéla Benedek; László G Hársing; Gábor Szénási |
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Publication Detail:
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Type: Journal Article Date: 2010-07-13 |
Journal Detail:
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Title: European journal of pharmacology Volume: 644 ISSN: 1879-0712 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-08-17 Completed Date: 2010-12-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 154-9 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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EGIS Pharmaceuticals PLC, Division of Preclinical Research, 1106 Keresztúri út 30-38, Budapest, Hungary. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain Ischemia / etiology, physiopathology* Cerebral Arteries / physiopathology Free Radical Scavengers / pharmacology* Glycine / analogs & derivatives*, pharmacology Infarction, Middle Cerebral Artery / complications Male Muscle, Smooth, Vascular / physiopathology Potassium Chloride / pharmacology Rats Rats, Sprague-Dawley Reperfusion Injury / complications Serotonin / pharmacology Sulfhydryl Compounds / pharmacology* Time Factors Vasoconstriction / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Free Radical Scavengers; 0/N-(2-mercaptoproprionyl)-glycine; 0/Sulfhydryl Compounds; 50-67-9/Serotonin; 56-40-6/Glycine; 7447-40-7/Potassium Chloride |
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