Document Detail

Decreased vasoconstrictor responses in remote cerebral arteries after focal brain ischemia and reperfusion in the rat, in vitro.
MedLine Citation:
PMID:  20621085     Owner:  NLM     Status:  MEDLINE    
The effects of brain ischemia and reperfusion on smooth muscle function in remote cerebral and peripheral arteries are hardly known. Maximum vasoconstrictions (E(max)) caused by 120mmol/l KCl and 5-HT in endothelium-denuded ring preparations were measured in ischemic and control cerebral arteries of rats after a 1-h right middle cerebral artery occlusion followed by 0-min (I/NR) or 2-3-min (I/SR) reperfusion, and in peripheral arteries after I/SR. Surprisingly, vasoconstrictions to 5-HT and 120mmol/lK(+) were attenuated in remote brain vessels after I/SR, i.e. in the contralateral middle cerebral artery and the basilar artery, while I/NR depressed E(max) of 5-HT and high KCl only in the ischemic middle cerebral artery. Pretreatment with N-(2-mercaptopropionyl) glycine (MPG, 100mg/kg i.p.), a free radical scavenger, fully prevented the impairment of vasomotor function in the middle cerebral artery on both sides after I/SR. Moreover, vasomotor functions were normal in the coronary, renal and pulmonary arteries after I/SR. In conclusion, focal cerebral ischemia and reperfusion impaired vasoconstrictor responses in remote brain arteries of rats by a mechanism involving free radicals. The lack of similar effects in peripheral vessels indicates poor defence of brain arteries against remote injury caused by reactive oxygen species-dependent mechanisms.
Anikó Kovács; Krisztina Móricz; Mihály Albert; Angéla Benedek; László G Hársing; Gábor Szénási
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Publication Detail:
Type:  Journal Article     Date:  2010-07-13
Journal Detail:
Title:  European journal of pharmacology     Volume:  644     ISSN:  1879-0712     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-08-17     Completed Date:  2010-12-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  154-9     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier B.V. All rights reserved.
EGIS Pharmaceuticals PLC, Division of Preclinical Research, 1106 Keresztúri út 30-38, Budapest, Hungary.
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MeSH Terms
Brain Ischemia / etiology,  physiopathology*
Cerebral Arteries / physiopathology
Free Radical Scavengers / pharmacology*
Glycine / analogs & derivatives*,  pharmacology
Infarction, Middle Cerebral Artery / complications
Muscle, Smooth, Vascular / physiopathology
Potassium Chloride / pharmacology
Rats, Sprague-Dawley
Reperfusion Injury / complications
Serotonin / pharmacology
Sulfhydryl Compounds / pharmacology*
Time Factors
Vasoconstriction / drug effects*
Reg. No./Substance:
0/Free Radical Scavengers; 0/N-(2-mercaptoproprionyl)-glycine; 0/Sulfhydryl Compounds; 50-67-9/Serotonin; 56-40-6/Glycine; 7447-40-7/Potassium Chloride

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