Document Detail


Decreased vascular sensitivity after acute exercise and chronic exercise training in rat thoracic aorta.
MedLine Citation:
PMID:  8896044     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of acute and chronic physical exercise on the sensitivity of isolated aorta to norepinephrine were investigated. After chronic exercise, the EC50 values for norepinephrine increased 3.1-fold and 2.3-fold in endothelium-intact and in endothelium-denuded aorta, respectively. The attenuated sensitivity of aorta to norepinephrine after chronic exercise was still evident in endothelium-denuded aorta, but to a lesser extent than in endothelium-intact aorta. After acute exercise, in control rats, the EC50 values increased 7.8-fold and 5.4-fold in endothelium-intact and endothelium-denuded aorta, respectively. The attenuated sensitivity of aorta to norepinephrine after an acute exercise was still evident in endothelium-denuded aorta. In trained rats, the EC50 values increased 2.3-fold and 2.6-fold in endothelium-intact and endothelium-denuded aorta, respectively. Thus, acute exercise was less effective in trained than in control rats. No significant difference in 60 mM KCl-induced tension between control and trained rats was observed with or without endothelium after acute and chronic exercise. The results suggest that levels of endothelium-dependent releasing factor may increase in response to norepinephrine after acute and chronic exercise. In addition, the attenuated sensitivity of aorta to norepinephrine after acute and chronic exercise may also result from the change(s) in the receptor sites. However, the degree of desensitization caused by acute exercise was less in the rats adapted to chronic exercise than in the sedentary control rats.
Authors:
T Izawa; M Morikawa; T Mizuta; J Nagasawa; T Kizaki; S Oh-ishi; H Ohno; T Komabayashi
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Research communications in molecular pathology and pharmacology     Volume:  93     ISSN:  1078-0297     ISO Abbreviation:  Res. Commun. Mol. Pathol. Pharmacol.     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1997-01-31     Completed Date:  1997-01-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9437512     Medline TA:  Res Commun Mol Pathol Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  331-42     Citation Subset:  IM    
Affiliation:
Department of Health and Sports Sciences, University of Electro-Communications, Chofu, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic alpha-Agonists / pharmacology*
Animals
Aorta, Thoracic / drug effects*,  physiology*
Body Weight / physiology
Endothelium, Vascular / physiology
Kinetics
Male
Norepinephrine / pharmacology*
Physical Conditioning, Animal / physiology*
Rats
Rats, Wistar
Sensitivity and Specificity
Time Factors
Vasoconstrictor Agents / pharmacology*
Chemical
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Vasoconstrictor Agents; 51-41-2/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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