Document Detail


Decreased vascular responsiveness produced by angiotensin-converting enzyme inhibitors in the rat isolated kidney.
MedLine Citation:
PMID:  6175573     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of three angiotensin converting enzyme (ACE) inhibitors - captopril, MK-421 diacid, and teprotide - on renal vascular responses to graded (50, 100, 200 ng) injections of norepinephrine (NE) were examined in rat isolated perfused kidneys, having a mean basal perfusion pressure of 78 +/- 10 mm Hg. The minimum dose of captopril (0.05 microgram/ml, low dose) that abolished the vasoconstrictor responses to 100 and 200 ng angiotensin I did not affect NE-induced renal vasoconstriction, whereas a dose 100 times greater (high-dose captopril, 5 micrograms/ml) reduced the vasoconstrictor action of NE. MK-421 diacid also at high dose (1 microgram/ml), caused similar reduction in renal vasoconstrictor responses to NE. In contrast, a high dose of teprotide (50 micrograms/ml) did not affect renal vascular responsiveness to NE. The threshold dose of NE that released prostaglandins, measured by bioassay, was 50 ng. Indomethacin (1 microgram/ml) prevented NE-induced release of prostaglandins but did not affect the ability of captopril to attenuate NE-induced vasoconstriction. We conclude that captopril and MK-421 diacid decreases vascular reactivity in the rat isolated kidney by a mechanism independent of ACE inhibition and unrelated to a prostaglandin-dependent vascular mechanism. Moreover, the presence of mercapto function in the ACE inhibitor is not essential since captopril, which has a sulfhydryl group, and MK-421 diacid, which lacks this group, have similar effects on renal vascular responsiveness.
Authors:
S Chiba; C P Quilley; J C McGiff
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hypertension     Volume:  4     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:    1982 May-Jun
Date Detail:
Created Date:  1982-06-24     Completed Date:  1982-06-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  80-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Angiotensin I / pharmacology
Angiotensin-Converting Enzyme Inhibitors*
Animals
Captopril / pharmacology
Dipeptides / pharmacology
Dose-Response Relationship, Drug
Enalapril
Indomethacin / pharmacology
Male
Norepinephrine / pharmacology
Prostaglandins / metabolism
Rats
Rats, Inbred Strains
Renal Circulation / drug effects*
Renin-Angiotensin System / drug effects
Teprotide / pharmacology
Vascular Resistance / drug effects*
Vasoconstriction / drug effects
Grant Support
ID/Acronym/Agency:
HL-25394-03/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Dipeptides; 0/Prostaglandins; 35115-60-7/Teprotide; 51-41-2/Norepinephrine; 53-86-1/Indomethacin; 62571-86-2/Captopril; 75847-73-3/Enalapril; 9041-90-1/Angiotensin I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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