Document Detail

Decreased vascular reactivity in metformin-treated fructose-hypertensive rats.
MedLine Citation:
PMID:  8781288     Owner:  NLM     Status:  MEDLINE    
We have previously demonstrated that long-term metformin treatment prevents the development of hyperinsulinemia and hypertension in fructose-hypertensive (FH) rats; however, the exact nature of its antihypertensive effects remains elusive. Since hyperinsulinemia has been proposed to be a strong stimulus for norepinephrine (NE) release, the present study examined the effects of long-term metformin treatment (500 mg/kg/d for 10 weeks) on the reactivity of superior mesenteric arteries to NE in FH rats. Metformin treatment prevented the development of hyperinsulinemia and hypertension in FH rats. Mesenteric arteries from FH rats exhibited an increased cross-sectional area ([CSA] 0.45 +/- 0.07 mm2 v 0.32 +/- 0.05 in controls, P < .05), which was prevented by long-term metformin treatment (0.34 +/- 0.04 mm2, p > .05 v untreated FH). Interestingly, mesenteric arteries from metformin-treated fructose and control rats exhibited a reduction in maximum responsiveness to NE both with and without the endothelium. These data suggest that metformin directly reduces catecholamine constrictor responses in resistance arteries of rats, which may contribute to its antihypertensive effects in rats.
S Verma; S Bhanot; J H McNeill
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  45     ISSN:  0026-0495     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1996-10-18     Completed Date:  1996-10-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1053-5     Citation Subset:  IM    
Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, Canada.
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MeSH Terms
Antihypertensive Agents / pharmacology,  therapeutic use*
Fructose / adverse effects*
Hyperinsulinism / prevention & control
Hypertension / drug therapy*,  physiopathology,  prevention & control
Hypoglycemic Agents / pharmacology,  therapeutic use*
Mesenteric Arteries / drug effects*,  physiopathology
Metformin / pharmacology,  therapeutic use*
Rats, Sprague-Dawley
Reg. No./Substance:
0/Antihypertensive Agents; 0/Hypoglycemic Agents; 30237-26-4/Fructose; 657-24-9/Metformin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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