| Decreased uptake of iodinated branched fatty acid analog indicates metabolic alterations in ischemic myocardium. | |
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MedLine Citation:
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PMID: 7472584 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We previously reported that uptake of 123I-labeled 15-iodophenyl 3-methyl pentadecanoic acid (BMIPP) was lower than that of thallium in ischemic myocardium. Such discordant findings between BMIPP and thallium were compared with those of PET using 18F-deoxyglucose (FDG) and 11C-acetate to assess metabolic alterations in such segment. METHODS: Sixteen patients with coronary artery disease underwent both BMIPP SPECT and PET. Relative FDG uptake (% FDG uptake) and the clearance rate constant (% Kmono) of 11C-acetate from the myocardium were calculated as markers of glucose and oxidative metabolism, respectively. RESULTS: Relative FDG uptake of the myocardial segments with reduced BMIPP uptake and normal thallium uptake (discordant segments) was similar (85.3 +/- 10.3) to that of the normal segments (86.5 +/- 11.7) but higher than that of segments with reduced uptake of both BMIPP and thallium (67.5 +/- 19.9). Similarly, the discordant segments showed a higher % Kmono value (77.8 +/- 13.1 versus 70.0 +/- 19.1) and FDG-to-perfusion ratio (1.15 +/- 0.08 versus 1.01 +/- 0.22) than in the concordantly reduced segments. CONCLUSION: BMIPP uptake appears to provide metabolic information independent of thallium uptake. Combined imaging of BMIPP and thallium may potentially identify ischemic but viable myocardium. |
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Authors:
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N Tamaki; E Tadamura; M Kawamoto; Y Magata; Y Yonekura; Y Fujibayashi; R Nohara; S Sasayama; J Konishi |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of nuclear medicine : official publication, Society of Nuclear Medicine Volume: 36 ISSN: 0161-5505 ISO Abbreviation: J. Nucl. Med. Publication Date: 1995 Nov |
Date Detail:
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Created Date: 1995-12-12 Completed Date: 1995-12-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0217410 Medline TA: J Nucl Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1974-80 Citation Subset: IM |
Affiliation:
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Department of Nuclear Medicine, Kyoto University Faculty of Medicine, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetates
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diagnostic use Carbon Radioisotopes / diagnostic use Coronary Disease / radionuclide imaging* Decanoic Acids / diagnostic use*, pharmacokinetics Deoxyglucose / analogs & derivatives, diagnostic use Fatty Acids* Female Fluorine Radioisotopes / diagnostic use Fluorodeoxyglucose F18 Heart / radionuclide imaging* Humans Iodine Radioisotopes / diagnostic use* Iodobenzenes / diagnostic use*, pharmacokinetics Male Middle Aged Myocardium / metabolism* Thallium Radioisotopes / diagnostic use Tomography, Emission-Computed Tomography, Emission-Computed, Single-Photon |
| Chemical | |
Reg. No./Substance:
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0/Acetates; 0/Carbon Radioisotopes; 0/Decanoic Acids; 0/Fatty Acids; 0/Fluorine Radioisotopes; 0/Iodine Radioisotopes; 0/Iodobenzenes; 0/Thallium Radioisotopes; 116754-87-1/iodofiltic acid; 154-17-6/Deoxyglucose; 63503-12-8/Fluorodeoxyglucose F18 |
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