Document Detail

Decreased total serum adiponectin and its isoforms in women with acute ischemic stroke.
MedLine Citation:
PMID:  22167134     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: An association between cerebral infarct risk factors and serum adiponectin levels (both total and separate isoforms) has previously been identified. The aim of this study was to assess circulating levels of all forms of adiponectin in the course of an ischemic stroke.
MATERIAL AND METHODS: Adiponectin and its isoforms (HMW, MMW and LMW) were measured in serum samples taken from 38 women in the first 24 hours of cerebral infarct and 38 controls matched for gender, body mass index (BMI) and age. In addition, biochemical parameters (glucose, insulin, lipid profile) and clinical data (blood pressure, weight, and height) were evaluated.
RESULTS: A significant reduction in serum levels of adiponectin and all examined fractions of this adipokine was observed in women suffering from acute ischemic stroke, compared with the matched controls.
CONCLUSIONS: Differences in the serum adiponectin array between stroke subjects and controls were identified and further studies are required to investigate the clinical implications of this finding.
Boguslawa Baranowska; Jan Kochanowski; Mariusz Grudniak; Agnieszka Baranowska-Bik; Ewa Wolinska-Witort; Lidia Martynska; Wojciech Bik
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuro endocrinology letters     Volume:  32     ISSN:  0172-780X     ISO Abbreviation:  Neuro Endocrinol. Lett.     Publication Date:  2011  
Date Detail:
Created Date:  2012-01-30     Completed Date:  2012-03-22     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  8008373     Medline TA:  Neuro Endocrinol Lett     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  711-5     Citation Subset:  IM    
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MeSH Terms
Acute Disease
Adiponectin / blood,  chemistry
Aged, 80 and over
Blood Glucose / metabolism
Body Mass Index
Brain Ischemia / epidemiology,  metabolism*
Lipids / blood
Molecular Weight
Risk Factors
Stroke / epidemiology,  metabolism*
Reg. No./Substance:
0/ADIPOQ protein, human; 0/Adiponectin; 0/Blood Glucose; 0/Lipids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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