| Decreased tobacco-glycoprotein-induced lymphocyte proliferation in vitro in pulmonary eosinophilic granuloma. | |
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MedLine Citation:
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PMID: 7812544 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pulmonary eosinophilic granuloma is a disorder caused by localized collections of proliferating histiocytes in the lung. Little is known about its etiology except that the majority (58 to 97%) of patients are current or ex-smokers, making the potential etiologic role of tobacco products an important area for research. Tobacco glycoprotein (TGP) is a potent immunostimulator that has been isolated from cigarette smoke. TGP-specific lymphocyte proliferation, and cytokine production in vitro, were measured in three patients with pulmonary eosinophilic granuloma in remission and in three closely matched normal subjects with similar smoking histories. One patient with eosinophilic granuloma of bone and a matched control subject were also studied. Peripheral blood mononuclear cells were cultured with TGP, the recall antigen streptokinase (SK), and the mitogen concanavalin A (Con A). All three of the patients with pulmonary eosinophilic granuloma exhibited significant decreases in lymphocyte stimulation to TGP, despite normal responses to SK and Con A. In contrast, the response of the patient with eosinophilic granuloma of bone was higher than her matched control. The mean responses of the patients with pulmonary eosinophilic granuloma to TGP was significantly lower than the mean of nondiseased smokers or of normal nonsmokers. Twenty-four-hour culture supernatants were collected and assayed for cytokine levels (IL-1, IL-2, and IL-6). TGP-stimulated IL-2 production was significantly lower in the patients with pulmonary eosinophilic granuloma than in the normal subjects, confirming the reduced T-cell proliferative response.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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L H Youkeles; J N Grizzanti; Z Liao; C J Chang; D L Rosenstreich |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of respiratory and critical care medicine Volume: 151 ISSN: 1073-449X ISO Abbreviation: Am. J. Respir. Crit. Care Med. Publication Date: 1995 Jan |
Date Detail:
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Created Date: 1995-02-09 Completed Date: 1995-02-09 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9421642 Medline TA: Am J Respir Crit Care Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 145-50 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analysis of Variance Cell Division / drug effects Cells, Cultured Eosinophilic Granuloma / blood*, etiology Female Glycoproteins / pharmacology* Humans Interleukins / blood Lung Diseases / blood*, etiology Lymphocytes / cytology, drug effects* Male Middle Aged Plants, Toxic* Smoking / blood Statistics, Nonparametric Tobacco* |
| Grant Support | |
ID/Acronym/Agency:
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AI 29871/AI/NIAID NIH HHS; P30-CA-13330/CA/NCI NIH HHS; T32 GM-7288/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Glycoproteins; 0/Interleukins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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