| Decreased survival of guinea pigs infected with Mycobacterium tuberculosis after multiple BCG vaccinations. | |
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MedLine Citation:
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PMID: 16153758 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The BCG vaccine for tuberculosis has an outstanding safety record, with only occasional reports of adverse reactions. In some countries multiple BCG vaccinations have been given to children, but with no apparent benefit. We show here that in the highly susceptible guinea pig model of Mycobacterium tuberculosis infection animals receiving three sequential injections of BCG began to die unexpectedly at times after aerosol challenge much earlier than animals receiving the vaccine only once. Animals receiving three injections with BCG had extensive, disseminated lesions in the lungs, spleen and liver that were similar to non-vaccinated animals. In these animals there was effacement of the pulmonary, hepatic and splenic architecture by extensive areas of fibrosis with residual granulomatous inflammation and necrosis. This contrasted to the saline control group in which active inflammation was accompanied by extensive areas of necrosis but with less fibrosis in the lungs and spleen. Granulomatous inflammation was less severe and was not complicated by necrosis or extensive fibrosis in animals receiving a single injection with BCG. These data indicate that multiple BCG vaccination, which is akin to super-infection with the living vaccine, leads to major organ failure pathology. |
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Authors:
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Randall J Basaraba; Angelo A Izzo; Lise Brandt; Ian M Orme |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2005-08-24 |
Journal Detail:
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Title: Vaccine Volume: 24 ISSN: 0264-410X ISO Abbreviation: Vaccine Publication Date: 2006 Jan |
Date Detail:
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Created Date: 2005-12-19 Completed Date: 2006-02-27 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8406899 Medline TA: Vaccine Country: Netherlands |
Other Details:
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Languages: eng Pagination: 280-6 Citation Subset: IM |
Affiliation:
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Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA. basaraba@colostate.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adjuvants, Immunologic
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adverse effects* Animals BCG Vaccine / adverse effects* Female Guinea Pigs Liver / pathology Lung / pathology Mycobacterium tuberculosis / immunology* Spleen / pathology Survival Analysis Tuberculosis / immunology*, mortality*, pathology Vaccination / adverse effects |
| Grant Support | |
ID/Acronym/Agency:
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AI-0400091/AI/NIAID NIH HHS; AI-054697/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Adjuvants, Immunologic; 0/BCG Vaccine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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