Document Detail


Decreased survival among sedentary patients undergoing dialysis: results from the dialysis morbidity and mortality study wave 2.
MedLine Citation:
PMID:  12552509     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Sedentary behavior is associated with an increased risk for death in the general population. However, the association between inactivity and mortality has not been studied in a large cohort of dialysis patients despite the high prevalence of sedentary behavior in this group. METHODS: We used the Dialysis Morbidity and Mortality Study Wave 2, a prospective study of a national sample of 4,024 incident peritoneal dialysis and hemodialysis patients from 1996 to 1997, to determine whether sedentary behavior is associated with increased mortality during a 1-year period in this group after adjusting for confounding variables. RESULTS: The study population consisted of the 2,837 patients with accurate survival data who were able to ambulate and transfer. Eleven percent of the sedentary patients died during the study period compared with 5% of nonsedentary patients. In a survival analysis, sedentary behavior (hazard ratio, 1.62; 95% confidence interval, 1.16 to 2.27) was associated with an increased risk for death at 1 year after adjusting for all variables that we postulated might be associated with survival and for differences between sedentary and nonsedentary patients. CONCLUSION: Sedentary behavior is associated with an increased risk for mortality among dialysis patients similar in magnitude to that of other well-established risk factors, such as a one-point reduction in serum albumin concentration. More attention should be given to exercise behavior in dialysis patients, and controlled clinical trials are needed to further define the association of sedentary behavior with mortality.
Authors:
Ann M O'Hare; Katherine Tawney; Peter Bacchetti; Kirsten L Johansen
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of kidney diseases : the official journal of the National Kidney Foundation     Volume:  41     ISSN:  1523-6838     ISO Abbreviation:  Am. J. Kidney Dis.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-01-28     Completed Date:  2003-02-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8110075     Medline TA:  Am J Kidney Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  447-54     Citation Subset:  IM    
Copyright Information:
Copyright 2003 by the National Kidney Foundation, Inc.
Affiliation:
Departments of Medicine and Epidemiology and Biostatistics, University of California, San Francisco, CA, USA. annohare@yahoo.com.
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MeSH Terms
Descriptor/Qualifier:
Cardiovascular Diseases / epidemiology,  mortality,  prevention & control
Cerebrovascular Disorders / epidemiology,  mortality,  prevention & control
Cohort Studies
Cross-Sectional Studies
Exercise Therapy / methods*,  trends
Female
Follow-Up Studies
Health Behavior
Health Surveys
Humans
Male
Middle Aged
Peripheral Vascular Diseases / epidemiology,  mortality,  prevention & control
Peritoneal Dialysis / methods,  mortality*
Prospective Studies
Questionnaires
Renal Dialysis / methods,  mortality*
Sensitivity and Specificity
Survival Analysis

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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