| Decreased striatal dopamine transporter binding in vivo in chronic schizophrenia. | |
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MedLine Citation:
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PMID: 11595398 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have previously reported that average striatal dopamine transporter (DAT) binding in vivo is unaltered in neuroleptic-naive first-episode schizophrenic patients [Laakso et al., Am. J. Psychiatry 157 (2000) 269]. However, as it has been suggested that some of the brain changes in schizophrenia may vary depending on the illness phase, we studied DAT density in eight stable, medicated chronic schizophrenic patients and eight matched controls using positron emission tomography and [18F]CFT, a marker of dopamine nerve terminals. [18F]CFT binding potentials were significantly lower in chronic schizophrenic patients than in controls, both in the caudate and the putamen (-9 to -16%). Together with the finding of unchanged average striatal DAT levels in first-episode patients and relative insensitivity of striatal [18F]CFT binding to endogenous dopamine and neuroleptic drugs, the result is in line with a relative loss of striatal dopaminergic nerve terminals and/or decreased expression of DAT in a subset of chronic schizophrenic patients. |
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Authors:
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A Laakso; J Bergman; M Haaparanta; H Vilkman; O Solin; E Syvälahti; J Hietala |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Schizophrenia research Volume: 52 ISSN: 0920-9964 ISO Abbreviation: Schizophr. Res. Publication Date: 2001 Oct |
Date Detail:
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Created Date: 2001-10-11 Completed Date: 2001-12-18 Revised Date: 2010-09-02 |
Medline Journal Info:
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Nlm Unique ID: 8804207 Medline TA: Schizophr Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 115-20 Citation Subset: IM |
Affiliation:
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Department of Pharmacology and Clinical Pharmacology, University of Turku, 20520, Turku, Finland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Brain Mapping Chronic Disease Cocaine / analogs & derivatives*, pharmacokinetics Corpus Striatum / radionuclide imaging* Dominance, Cerebral / physiology Dopamine Plasma Membrane Transport Proteins Dopamine Uptake Inhibitors / pharmacokinetics Female Humans Male Membrane Glycoproteins* Membrane Transport Proteins / metabolism* Nerve Tissue Proteins* Psychiatric Status Rating Scales Radioligand Assay Schizophrenia / physiopathology, radionuclide imaging* Tomography, Emission-Computed* |
| Chemical | |
Reg. No./Substance:
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0/Dopamine Plasma Membrane Transport Proteins; 0/Dopamine Uptake Inhibitors; 0/Membrane Glycoproteins; 0/Membrane Transport Proteins; 0/Nerve Tissue Proteins; 0/SLC6A3 protein, human; 50-36-2/Cocaine; 50370-56-4/(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester |
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