Document Detail

Decreased spontaneous heart rate variability in congestive heart failure.
MedLine Citation:
PMID:  2816768     Owner:  NLM     Status:  MEDLINE    
Heart rate (HR) variability is a noninvasive index of the neural activity of the heart. Although also dependent on the sympathetic activity of the heart, HR variability is mainly determined by the vagal outflow of the heart. Several HR abnormalities have been described in patients with congestive heart failure (CHF); however, there are no data on HR variability in CHF patients. In the present study HR variability was assessed in 20 CHF patients and 20 control subjects from 24-hour Holter tapes. HR variability was evaluated by calculating the mean hourly HR standard deviation and by analyzing the 24-hour RR histogram. Mean hourly HR standard deviation was markedly and significantly reduced in CHF patients both over the 24-hour period (97.5 +/- 41 vs 233.2 +/- 26 ms, p less than 0.001) as well as during most of the individual hours examined. The 24-hour RR histogram of CHF patients had a different shape and had a decreased variation compared to control subjects (total variability 356 +/- 102 vs 757 +/- 156 ms, p less than 0.001). Thus, CHF patients with depressed ejection fraction (less than 30%) have a low HR variability compared to normal individuals. This result can be interpreted as adjunctive evidence for decreased parasympathetic activity to the heart during CHF.
G Casolo; E Balli; T Taddei; J Amuhasi; C Gori
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of cardiology     Volume:  64     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1989 Nov 
Date Detail:
Created Date:  1989-12-15     Completed Date:  1989-12-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1162-7     Citation Subset:  AIM; IM    
Clinica Medica I, University of Florence, Italy.
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MeSH Terms
Circadian Rhythm*
Electrocardiography, Ambulatory
Heart Catheterization
Heart Failure / physiopathology*
Heart Rate / physiology*
Middle Aged
Signal Processing, Computer-Assisted
Sleep / physiology

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