Document Detail

Decreased somatostatin-like immunoreactivity in the cerebrospinal fluid of chronic schizophrenic patients with cognitive impairment.
MedLine Citation:
PMID:  2243905     Owner:  NLM     Status:  MEDLINE    
The level of cerebrospinal fluid somatostatin-like immunoreactivity (CSF SLI) was determined for 11 chronic schizophrenic patients with moderate cognitive impairment and for 8 controls. The CSF SLI was significantly reduced (37%) in schizophrenic patients, but this decrease did not correlate with the degree of cognitive decline measured by the Mini-Mental State Examination, with psychotic symptoms estimated by the Brief Psychiatric Rating Scale, or with the neuroleptic dose. Although a reducing effect of long-term neuroleptic treatment cannot be totally excluded, the present study suggests that the CSF SLI level is decreased in cognitively impaired schizophrenic patients, as in many other disorders with cognitive impairment.
K J Reinikainen; H Koponen; J Jolkkonen; P J Riekkinen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Psychiatry research     Volume:  33     ISSN:  0165-1781     ISO Abbreviation:  Psychiatry Res     Publication Date:  1990 Sep 
Date Detail:
Created Date:  1991-01-03     Completed Date:  1991-01-03     Revised Date:  2008-04-17    
Medline Journal Info:
Nlm Unique ID:  7911385     Medline TA:  Psychiatry Res     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  307-12     Citation Subset:  IM    
Kuopio University Central Hospital, Finland.
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MeSH Terms
Chronic Disease
Cognition Disorders / cerebrospinal fluid*,  diagnosis
Delirium, Dementia, Amnestic, Cognitive Disorders / cerebrospinal fluid*,  diagnosis
Dementia / cerebrospinal fluid
Mental Status Schedule
Middle Aged
Peptides / cerebrospinal fluid*
Schizophrenia / cerebrospinal fluid*,  diagnosis
Schizophrenic Psychology*
Reg. No./Substance:
0/Peptides; 0/somatostatin-like peptides

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