Document Detail

Decreased serum levels of insulin-like growth factors and IGF binding protein 3 in osteoporosis.
MedLine Citation:
PMID:  7689089     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The aim of the study was to investigate endogenous growth hormone (GH) secretion in patients with osteoporosis and in patients with degenerative bone diseases or no spinal disease by measuring serum insulin-like growth factors 1 and 2 (IGFs) and their major binding protein 3 (BP-3) as an indirect parameter of GH secretion. DESIGN: A cross-sectional study. SETTING: All patients were seen as out-patients of the Endocrinology Department of the University of Heidelberg where all bone parameters were measured. IGFs and BP-3 serum levels were measured at the Children's Hospital of the University of T?bingen. SUBJECTS: A total number of 310 patients were studied. The group with primary osteoporosis and vertebral fractures (OPO) consisted of 141 patients (98 females, 43 males). Spinal degenerative bone disease or osteoarthritis (DEG) was present in 108 patients (91 females, 17 males). Sixty-one control patients (56 females, 5 males) had no spinal disease on X-ray, but presented with lower back pain. MAIN OUTCOME MEASURES: Serum levels of IGFs, BP-3, PTH and 25-vitamin D3 were measured by radioimmunoassay. Bone mineral density (BMD) was determined using absorptiometry; anthropometric parameters and menopausal status were recorded. RESULTS: There was no difference in age and years after menopause between OPO and DEG, but control individuals were younger. Mean IGFs and BP-3 serum levels in patients with OPO were lower (P < 0.001) than those in patients with DEG or in controls. Patients with DEG had significantly higher BP-3 levels than controls (P < 0.001). There was a significant (P < 0.05) negative correlation of BP-3 with age in females with OPO, but not in controls or in DEG patients. The IGFs did not decrease with age in any of the three groups. Binding protein 3 was positively correlated (P < 0.05) with BMD in postmenopausal women with OPO but not in controls or DEG patients. CONCLUSION: We conclude that systemic IGFs and IGF binding protein 3 are decreased in patients with osteoporosis. Further studies are needed to investigate whether this is as a result of diminished secretion of endogenous GH and whether this reflects the local circumstances of IGFs and IGF binding proteins in bone.
C W?ster; W F Blum; S Schlemilch; M B Ranke; R Ziegler
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of internal medicine     Volume:  234     ISSN:  0954-6820     ISO Abbreviation:  J. Intern. Med.     Publication Date:  1993 Sep 
Date Detail:
Created Date:  1993-09-22     Completed Date:  1993-09-22     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  8904841     Medline TA:  J Intern Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  249-55     Citation Subset:  IM    
Department of Internal Medicine I, Endocrinology and Metabolism, University of Heidelberg, Germany.
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MeSH Terms
Bone Density
Carrier Proteins / blood*
Cross-Sectional Studies
Insulin-Like Growth Factor Binding Proteins
Low Back Pain / blood
Middle Aged
Osteoarthritis / blood
Osteoporosis / blood*
Osteoporosis, Postmenopausal / blood
Regression Analysis
Somatomedins / metabolism*
Reg. No./Substance:
0/Carrier Proteins; 0/Insulin-Like Growth Factor Binding Proteins; 0/Somatomedins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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