| Decreased serum level of tumor necrosis factor in animals treated with lipopolysaccharide and liposomes containing phosphatidylserine. | |
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MedLine Citation:
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PMID: 1576245 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The rise in serum level of tumor necrosis factor (TNF), produced by lipopolysaccharide, has been measured in mice and rabbits treated with phospholipid liposomes. After 3 daily ip injection (mice) or 5 daily i.v. injections (rabbits) of 30 mg/kg of a phospholipid mixture enriched in phosphatidylserine, the action of lipopolysaccharide was 80-90% reduced. The phospholipid effect is dose dependent, requires a minimum of two daily injections before the administration of lipopolysaccharide, and is still manifest 2 days after the last phospholipid dose. Among individual purified phospholipids, phosphatidylserine and phosphatidylethanolamine were effective whereas phosphatidylinositol, phosphatidylglycerol, and phosphatidylcholine did not show significant activity. The data indicate that the parenteral administration of liposomes containing the aminophospholipids phosphatidylserine, and phosphatidylethanolamine is an efficient mode to reduce the endotoxin-induced production of TNF. As suggested by liposome pharmacokinetics, this effect may be related to phospholipid accumulation in the mononuclear phagocyte system of liver and spleen. |
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Authors:
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G Monastra; A Bruni |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Lymphokine and cytokine research Volume: 11 ISSN: 1056-5477 ISO Abbreviation: Lymphokine Cytokine Res. Publication Date: 1992 Feb |
Date Detail:
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Created Date: 1992-06-05 Completed Date: 1992-06-05 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9107882 Medline TA: Lymphokine Cytokine Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 39-43 Citation Subset: IM |
Affiliation:
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Fidia Research Laboratories, Abano Terme (Padova), Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chromatography, Thin Layer Dose-Response Relationship, Drug Lipopolysaccharides / immunology* Liposomes Male Mice Phosphatidylethanolamines / administration & dosage, pharmacology Phosphatidylglycerols / administration & dosage, pharmacology Phosphatidylinositols / administration & dosage, pharmacology Phosphatidylserines / administration & dosage, pharmacology* Phospholipids / administration & dosage, pharmacology* Rabbits Tumor Necrosis Factor-alpha / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Lipopolysaccharides; 0/Liposomes; 0/Phosphatidylethanolamines; 0/Phosphatidylglycerols; 0/Phosphatidylinositols; 0/Phosphatidylserines; 0/Phospholipids; 0/Tumor Necrosis Factor-alpha |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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