| Decreased serum essential and aromatic amino acids in patients with chronic pancreatitis. | |
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MedLine Citation:
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PMID: 20845509 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To investigate the influence of chronic pancreatitis (CP) on serum concentrations of amino acids. METHODS: Thirty-five male patients with alcoholic CP and 21 healthy male subjects were examined. Serum concentrations of amino acids were assayed by ion-pair high-performance liquid chromatography with mass detection. RESULTS: Serum glutamate concentration was increased in CP patients as compared to controls. In contrast, serum concentrations of glutamine, histidine, tyrosine, proline, tryptophan and threonine were significantly decreased in CP patients. A trend towards decreasing concentrations of serum lysine, alanine, methionine and valine as well as for total serum amino acids was observed. The sum of aromatic and the sum of essential amino acid concentrations were significantly lower in CP patients than in controls. CONCLUSION: CP leads to decreased serum concentrations of several amino acids, such as essential and aromatic serum amino acids, most likely due to decreased exocrine function. |
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Authors:
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Krystian Adrych; Marian Smoczynski; Magdalena Stojek; Tomasz Sledzinski; Ewa Slominska; Elzbieta Goyke; Ryszard-Tomasz Smolenski; Julian Swierczynski |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: World journal of gastroenterology : WJG Volume: 16 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-16 Completed Date: 2011-01-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
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Languages: eng Pagination: 4422-7 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, Medical University of Gdansk, ul. Debinki 1, 80-211 Gdansk, Poland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Amino Acids, Aromatic / blood* Amino Acids, Essential / blood* Humans Male Middle Aged Pancreatitis, Chronic / blood* |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids, Aromatic; 0/Amino Acids, Essential |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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