Document Detail

Decreased serum apolipoprotein B-100 and A-I concentrations in cows with ketosis and left displacement of the abomasum.
MedLine Citation:
PMID:  9028472     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the relevance of hepatic lipidosis (fatty liver) in the development of ketosis and left displacement of the abomasum (LDA). SAMPLE POPULATION: Sera from 22 healthy cows in early lactation, 21 cows with ketosis, and 19 cows with LDA, and serum and liver specimens from 35 slaughtered cows with or without fatty liver, ketosis, and/or LDA. PROCEDURE: Apolipoprotein B-100 and A-I concentrations were measured in sera of healthy farm cows and of farm cows with ketosis and LDA. Serum apolipoprotein concentration, together with liver triglyceride content, also were surveyed in a subset of slaughtered cows. RESULTS: Compared with those in healthy cows or controls, apolipoprotein B-100 and A-I concentrations were decreased in cows with ketosis and LDA. CONCLUSIONS: Decreases in apolipoprotein B-100 and A-I concentrations in cows with ketosis and LDA indicate that the 2 disorders may be intimately associated with fatty liver. CLINICAL RELEVANCE: Monitoring of the apolipoprotein B-100 and A-I concentrations during the stages of nonlactation and early lactation is helpful for detecting cows susceptible to ketosis and LDA.
S Oikawa; N Katoh; F Kawawa; Y Ono
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of veterinary research     Volume:  58     ISSN:  0002-9645     ISO Abbreviation:  Am. J. Vet. Res.     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-06-03     Completed Date:  1997-06-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375011     Medline TA:  Am J Vet Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  121-5     Citation Subset:  IM    
Morioka Livestock Hygiene Service Center, Iwate, Japan.
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MeSH Terms
3-Hydroxybutyric Acid
Abomasum / abnormalities*
Apolipoprotein A-I / blood*
Apolipoprotein B-100
Apolipoproteins B / blood*
Biological Markers / blood
Cattle / abnormalities*
Cattle Diseases*
Fatty Acids, Nonesterified / blood
Hydroxybutyrates / blood
Ketosis / blood,  metabolism,  veterinary*
Liver / metabolism*
Reference Values
Triglycerides / metabolism*
Reg. No./Substance:
0/Apolipoprotein A-I; 0/Apolipoprotein B-100; 0/Apolipoproteins B; 0/Biological Markers; 0/Fatty Acids, Nonesterified; 0/Hydroxybutyrates; 0/Triglycerides; 300-85-6/3-Hydroxybutyric Acid

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