Document Detail

Decreased reverse T3 levels in neonates with central hypothyroidism.
MedLine Citation:
PMID:  9069058     Owner:  NLM     Status:  MEDLINE    
Concern arises when a sick infant is found to have a low serum T4, normal thyroid hormone binding, and a nonelevated thyroid-stimulating hormone. Hypothyroxinemia in this situation can result from either euthyroid sick syndrome or central hypothyroidism. To help distinguish between these diagnostic possibilities, we have measured reverse T3 and other thyroid function chemistries in six neonates who have central hypothyroidism in association with hypopituitarism. We found that these infants all had reverse T3 levels that were much lower than reported normal levels for premature and term neonates. This finding suggests that low reverse T3 levels can help to distinguish infants with central hypothyroidism from sick and well infants who tend to have relatively elevated reverse T3 levels.
E M Faase; L R Meacham; C M Novack; M I Brakin; H D Mosier; F L Culler
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  17     ISSN:  0743-8346     ISO Abbreviation:  J Perinatol     Publication Date:    1997 Jan-Feb
Date Detail:
Created Date:  1997-06-16     Completed Date:  1997-06-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  15-7     Citation Subset:  IM    
Department of Pediatrics, Emory University School of Medicine, Atlanta, USA.
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MeSH Terms
Diagnosis, Differential
Hyperthyroxinemia / diagnosis*,  genetics
Hypopituitarism / complications,  diagnosis,  genetics
Hypothyroidism / blood,  complications,  diagnosis*,  genetics
Infant, Newborn
Reference Values
Thyroid Function Tests
Thyrotropin / analysis,  blood
Thyroxine / blood*
Triiodothyronine, Reverse / analysis,  blood*
Reg. No./Substance:
5817-39-0/Triiodothyronine, Reverse; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin

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