| Decreased renal plasma flow during propranolol treatment in essential hypertension. | |
| | |
MedLine Citation:
|
PMID: 760408 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The pharmacodynamic effect of propranolol (80 mg b.i.d.) on the renal and systemic circulation was studied after 1 and 8 months of treatment in 13 patients with essential hypertension, using non-invasive radioisotope techniques. Effective renal plasma flow (ERPF) fell from (mean +/- S.E.M.) 244 +/- 18 to 208 +/- 14 after 1 month and to 187 +/- 13 ml/min.m2 after 8 months of treatment. Concomitantly cardiac index (CI) fell from 3.24 +/- 0.15 to 2.62 +/- 0.11 and 2.75 +/- 0.10 l/min.m2, respectively. The coefficient of correlation between the decreases in ERPF and CI was 0.49. Mean arterial blood pressure decreased from 138 +/- 5 to 118 +/- 5 and 116 +/- 4 mmHg, respectively. Left ventricular work was reduced by 30.2 and 27%, while peripheral resistance was unchanged. Total plasma volume was increased from 19.3 +/- 0.5 to 20.3 +/- 0.6 ml/cm after 1 month, but was within the same range as the control values after 8 months of treatment. Pulmonary plasma volume was unchanged, indicating that there was no pooling of plasma in the pulmonary circulation. The interventricular circulation time was increased from 6.9 +/- 0.4 s to 8.4 +/- 0.3 s and varied with the change in heart rate. It is concluded that the fall in ERPF might be explained by reduced cardiac output in addition to interference with the hemodynamic autoregulation in the kidney. |
| | |
Authors:
|
D K Falch; A E Odegaard; N Norman |
Related Documents
:
|
10583448 - Renal hemodynamic changes during smoking: effects of adrenoreceptor blockade. 1951738 - Renal hemodynamic changes during serial seizures in rats. 7756098 - Amlodipine and haemodynamic effects of cyclo-oxygenase inhibition. 2769358 - Responses of primate spinothalamic tract neurons to renal pelvic distension. 14563688 - Myosin heavy chain expression in renal afferent and efferent arterioles: relationship t... 1824648 - Preliminary results of the norwegian doxazosin postmarketing surveillance study: a twel... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Acta medica Scandinavica Volume: 205 ISSN: 0001-6101 ISO Abbreviation: Acta Med Scand Publication Date: 1979 |
Date Detail:
|
Created Date: 1979-03-24 Completed Date: 1979-03-24 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0370330 Medline TA: Acta Med Scand Country: SWEDEN |
Other Details:
|
Languages: eng Pagination: 91-5 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Cardiac Output / drug effects* Female Heart Rate / drug effects Humans Hypertension / drug therapy* Kidney / blood supply*, drug effects Male Middle Aged Plasma Volume / drug effects Propranolol / adverse effects*, therapeutic use Regional Blood Flow / drug effects |
| Chemical | |
Reg. No./Substance:
|
525-66-6/Propranolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Menopausal age in relation to smoking.
Next Document: Febrile seizures.