Document Detail


Decreased renal plasma flow during propranolol treatment in essential hypertension.
MedLine Citation:
PMID:  760408     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pharmacodynamic effect of propranolol (80 mg b.i.d.) on the renal and systemic circulation was studied after 1 and 8 months of treatment in 13 patients with essential hypertension, using non-invasive radioisotope techniques. Effective renal plasma flow (ERPF) fell from (mean +/- S.E.M.) 244 +/- 18 to 208 +/- 14 after 1 month and to 187 +/- 13 ml/min.m2 after 8 months of treatment. Concomitantly cardiac index (CI) fell from 3.24 +/- 0.15 to 2.62 +/- 0.11 and 2.75 +/- 0.10 l/min.m2, respectively. The coefficient of correlation between the decreases in ERPF and CI was 0.49. Mean arterial blood pressure decreased from 138 +/- 5 to 118 +/- 5 and 116 +/- 4 mmHg, respectively. Left ventricular work was reduced by 30.2 and 27%, while peripheral resistance was unchanged. Total plasma volume was increased from 19.3 +/- 0.5 to 20.3 +/- 0.6 ml/cm after 1 month, but was within the same range as the control values after 8 months of treatment. Pulmonary plasma volume was unchanged, indicating that there was no pooling of plasma in the pulmonary circulation. The interventricular circulation time was increased from 6.9 +/- 0.4 s to 8.4 +/- 0.3 s and varied with the change in heart rate. It is concluded that the fall in ERPF might be explained by reduced cardiac output in addition to interference with the hemodynamic autoregulation in the kidney.
Authors:
D K Falch; A E Odegaard; N Norman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta medica Scandinavica     Volume:  205     ISSN:  0001-6101     ISO Abbreviation:  Acta Med Scand     Publication Date:  1979  
Date Detail:
Created Date:  1979-03-24     Completed Date:  1979-03-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370330     Medline TA:  Acta Med Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  91-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Cardiac Output / drug effects*
Female
Heart Rate / drug effects
Humans
Hypertension / drug therapy*
Kidney / blood supply*,  drug effects
Male
Middle Aged
Plasma Volume / drug effects
Propranolol / adverse effects*,  therapeutic use
Regional Blood Flow / drug effects
Chemical
Reg. No./Substance:
525-66-6/Propranolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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