Document Detail

Decreased renal excretion of uric acid following diuretic administration in rats.
MedLine Citation:
PMID:  6374219     Owner:  NLM     Status:  MEDLINE    
In order to evaluate the cause of diuretic-induced hyperuricemia which has been well documented in clinical studies, clearance experiments were performed in rats using furosemide and trichlormethiazide . The net flux in the tubular transport of uric acid was reabsorptive, and the fractional excretion of uric acid responded sensitively to the transtubular transport inhibitors, sodium probenecid and pyrazinoic acid. When the hemoconcentration was induced by highly potent doses of test diuretics, the inulin clearance and the fractional excretion of uric acid clearly decreased. The contraction of body fluid produced by intraperitoneal administration of polyethylene glycol resulted in marked decrease of inulin clearance and fractional excretion of uric acid. The decrease of uric acid excretory capacity under the treatment with trichlormethiazide was completely corrected by saline loading. Moreover, no significant change was found in the pyrazinoic acid-suppressible fractional excretion of uric acid between the diuretic-treated rats and the control animals. These studies suggest that furosemide- and trichlormethiazide -induced changes in the renal handling of uric acid are mediated by the fluid volume contraction and that the decrease in fractional excretion of uric acid by test diuretics is the result of reabsorptive enhancement of uric acid.
K Iwaki; Y Yonetani
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Japanese journal of pharmacology     Volume:  34     ISSN:  0021-5198     ISO Abbreviation:  Jpn. J. Pharmacol.     Publication Date:  1984 Apr 
Date Detail:
Created Date:  1984-07-25     Completed Date:  1984-07-25     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  2983305R     Medline TA:  Jpn J Pharmacol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  389-96     Citation Subset:  IM    
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MeSH Terms
Diuretics / pharmacology*
Furosemide / pharmacology
Insulin / blood,  urine
Probenecid / pharmacology
Pyrazinamide / analogs & derivatives,  pharmacology
Rats, Inbred Strains
Trichlormethiazide / pharmacology
Uric Acid / blood,  urine*
Reg. No./Substance:
0/Diuretics; 11061-68-0/Insulin; 133-67-5/Trichlormethiazide; 54-31-9/Furosemide; 57-66-9/Probenecid; 69-93-2/Uric Acid; 98-96-4/Pyrazinamide; 98-97-5/pyrazinoic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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